Search and the functional analysis of lipophilic signaling molecule as a regulator of adipogenesis in the ruminants.

• Project/Area Number: 20580304
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Shinshu University
• Principal Investigator: SASAKI Shin-ichi Shinshu University, 農学部, 教授 (00003682)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 反芻動物 / 脂肪細胞分化制御 / シグナル伝達 / 生理活性物質 / 核内転写因子 / 脂肪細胞形成 / 転写因子 / si RNA / PPARγ-2 / LXRα / Rev-Erbα / RXR / レチノイドX受容体 / 肝X受容体

Research Abstract

To date, the regulating mechanism of adipogenesis in the ruminants have not been clear. Therefore, we investigated the search and the functional analysis of lipophilic signaling molecule as a regulator of adipogenesis in the ruminants. In this study we demonstrated that VFA and lactoseureid are an intrinsic and an extrinsic factor, respectively, controlling the gene expression of PPAR γ-2 and LXRα in the ruminants, and VFA is a prominannt inducer and regulator on the ruminant adipocyte differentiation.

Research Products

• [Journal Article] Domest.Anim.Endocrinol. (2010)
  • Author(s): Song S.H., Fukui K., Nakajima K., Kozakai T., Sasaki S. Roh S.G, Katoh K.
  • Journal Title: 39 Pages: 97-105
  • Peer Reviewed
• [Journal Article] Cloning, expression analysis, and regulatory mechanisms of bovine chemerin and chemerin receptor. (2010)
  • Author(s): S.H.Song, S.Sasaki, et al.
  • Journal Title: Domest.Anim.Endocrinol Volume: 39 Pages: 97-105
  • Peer Reviewed
• [Journal Article] Differential action of trans-10, cis-12 conjugated linoleic acid on adipocyte differentiation of ovine and 3T3-L1 preadipocytes. (2009)
  • Author(s): Iga T., Satoh T., Yamamoto S., Fukui K.,Song S.H., Choi K.C., Roh S.G., Sasaki S.
  • Journal Title: Asian-Aust.J.Anim.Sci. 22 Pages: 1566-1573
  • Peer Reviewed
• [Journal Article] Prostatic androgen-repressed message-1 as a regulator of adipocyte differentiation in the mouse. (2009)
  • Author(s): Song S.H., Hong Y.H., Sasaki S.Roh S.G., Katoh K.
  • Journal Title: Tohoku J.Exp.Med. 219 Pages: 311-317
  • NAID: 10027082678
  • Peer Reviewed
• [Journal Article] Differential action of trans-10, cis-12 Conjugated Linoleic Acid on Adipo-cyte Differentiation of Ovine and 3T3-L1 Preadipocytes. (2009)
  • Author(s): T.Iga, S.Sasaki, et al.
  • Journal Title: Asian-Aust.J.Anim.Sci. 22 Pages: 1566-1573
  • Peer Reviewed
• [Presentation] 黒毛和種牛脂肪前駆細胞、BIP細胞およびC2C12細胞の増殖・分化に及ぼすラクトースウレイドおよびそのルーメン内代謝産物の影響 (2010)
  • Author(s): 米澤明彦、麻生久、盧尚建、濱野光市、米倉真一、佐々木晋一
  • Organizer: 第59回北信越畜産学会大会
  • Place of Presentation: 富山県
  • Year and Date: 2010-11-05
• [Presentation] 牛筋肉内脂肪前駆細胞株(BIP細胞)におけるレプチンの発現様式 (2010)
  • Author(s): 米倉真一、米澤明彦、麻生久、佐々木晋一
  • Organizer: 第59回北信越畜産学会大会
  • Place of Presentation: 富山県
  • Year and Date: 2010-11-05
• [Presentation] 黒毛和種牛脂肪前駆細胞、BIP細胞およびC2C12細胞の増殖・分化に及ぼすラクトースウレイドおよびそのルーメン内代謝産物の影響 (2010)
  • Author(s): 米澤明彦、佐々木晋, 他
  • Organizer: 第59回北信越畜産学会大会
  • Place of Presentation: 富山県立大学
  • Year and Date: 2010-11-05
• [Presentation] 加藤和雄脂肪細胞由来遺伝子 (2010)
  • Author(s): 盧尚建、宋相憲、鈴木裕、佐々木晋一
  • Organizer: adipogeninの発現調節について日本畜産学会大112回大会
  • Place of Presentation: 東京都
  • Year and Date: 2010-03-28