Search and the functional analysis of lipophilic signaling molecule as a regulator of adipogenesis in the ruminants.
| Project/Area Number |
20580304
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied animal science
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| Research Institution | Shinshu University |
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Principal Investigator |
SASAKI Shin-ichi Shinshu University, 農学部, 教授 (00003682)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 反芻動物 / 脂肪細胞分化制御 / シグナル伝達 / 生理活性物質 / 核内転写因子 / 脂肪細胞形成 / 転写因子 / si RNA / PPARγ-2 / LXRα / Rev-Erbα / RXR / レチノイドX受容体 / 肝X受容体 |
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| Research Abstract |
To date, the regulating mechanism of adipogenesis in the ruminants have not been clear. Therefore, we investigated the search and the functional analysis of lipophilic signaling molecule as a regulator of adipogenesis in the ruminants. In this study we demonstrated that VFA and lactoseureid are an intrinsic and an extrinsic factor, respectively, controlling the gene expression of PPAR γ-2 and LXRα in the ruminants, and VFA is a prominannt inducer and regulator on the ruminant adipocyte differentiation.
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Report
(4 results)
Research Products
(9 results)
