| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
The KIT receptor tyrosine kinase is required for normal spermatogenesis. Although spermatogenesis is abolished in the testis of W^v/W^v mice due to the Kit gene mutation, undifferentiated spermatogonia with spermatogonial stem cell (SSC) phenotype were identified. The W^v/W^v spermatogonia were self-renewed in a modified SSC culture system, indicating they were SSCs. Comparison of the gene expression profiles of the W^v/W^v and wild-type SSCs identified several genes that were expressed differentially in the two SSC populations. These genes might play a role in spermatogonial differentiation.
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