Release of purines and its mechanisms under ischemic conditions in spinal cord
Project/Area Number |
20580317
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
|
Research Institution | Hokkaido University |
Principal Investigator |
OTSUGURO Ken-ichi Hokkaido University, 大学院・獣医学研究科, 准教授 (40344494)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アデノシン / 脊髄 / 新生ラット / 反射電位 / 低酸素 / アシドーシス / 虚血 / イノシン / 脊髄反射電位 / A1受容体 / グリア / プリン化合物 / 高炭酸アシドーシス |
Research Abstract |
It is well-known that hypoxia and acidosis significantly influence neuronal functions under ischemic conditions. In this study, an electrical activity of spinal neuronal pathways and extracellular purine concentration were measured. Hypoxia and acidosis released not only adenosine but also inosine from the spinal cord, and adenosine suppressed the neuronal activities via adenosine A1 receptors. In addition, the influence of hypoxia largely depended on age, temperature and neuronal pathways. It is suggested that adenosine plays an important role in this phenomenon.
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Report
(4 results)
Research Products
(16 results)