| Project/Area Number |
20580324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
NAKAHARA Keiko University of Miyazaki, 農学部, 准教授 (90315359)
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| Research Collaborator |
MURAKAMI Noboru 宮崎大学, 農学部, 准教授
MIYAZATO Mikiya 国立循環器病研究センター研究所, 生化学, 部長
KANGAWA Kenji 国立循環器病研究センター研究所, 所長
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ニューロメジンS / ニューロメジンU / 生体時計 / 摂食 / 自律神経 / ノックアウトマウス / 視交叉上核 / 心拍数 / 循環器系 / バゾプレッシン / 抗利尿作用 / 血圧 / 循環器 |
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| Research Abstract |
I investigated physiological functions of neuromedin U and neuromedin S which was identified as a novel peptide in 2005. Both neuromedin S and neuromedin U play important role for oxytocin release as a mediator of sensory information. In addition, neuromedin S regulate feeding by acting downstream of the leptin signaling pathway. Neuromedin S KO mice decrease the heart rate, suggesting that endogenous neuromedin S may regulate cardiovascular function by acting on sympathetic nerve.
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