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Effect of hypertension and hyperlipidemia on diabetic peripheral neuropathy

Research Project

Project/Area Number 20580332
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionSetsunan University

Principal Investigator

OZAKI Kiyokazu  Setsunan University, 薬学部, 講師 (40268496)

Co-Investigator(Kenkyū-buntansha) NARAMA Isao  摂南大学, 薬学部, 教授 (80268490)
MATSUURA Tetsuro  摂南大学, 薬学部, 講師 (20268494)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords末梢神経 / 糖尿病 / 高血圧 / 高脂血症 / ラット / 腎臓摘出 / 組織学
Research Abstract

To investigate the effects of mild hypertension after unilateral nephrectomy, and hyperlipidemia induced by feeding of high-fat diet on diabetic peripheral neuropathy, we examined the peripheral nerves of diabetic WBN/Kob and ZDF rats, Mild hypertension and hypertriglyceridemia were induced in both animals. However, nerve conduction velocity and morphological lesions of peripheral nerves were comparable in all groups. These findings indicate that unilateral nephrectomy and hypertriglyceridemia have little effect on diabetic peripheral neuropathy.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2010

All Presentation (4 results)

  • [Presentation] 糖尿病を早期発症させたWBN/Kobラットに対する片側腎摘出による糖尿病性末梢神経病変の増悪化の試み2010

    • Author(s)
      濱野紘子、尾崎清和
    • Organizer
      日本薬学会近畿支部集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-10-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 糖尿病を早期発症させたWBN/Kobラットに対する片側腎摘出による糖尿病性末梢神経病変の増悪化の試み2010

    • Author(s)
      濱野紘子、尾崎清和
    • Organizer
      日本薬学会近畿支部集会
    • Place of Presentation
      大阪府枚方市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 自然発症および薬物誘発性糖尿病ラットの腎臓および末梢神経病変の病理2010

    • Author(s)
      尾崎清和
    • Organizer
      日本毒性病理学会
    • Place of Presentation
      金沢
    • Year and Date
      2010-02-04
    • Related Report
      2010 Final Research Report
  • [Presentation] 自然発症および薬物誘発性糖尿病ラットの腎臓および末梢神経病変の病理2010

    • Author(s)
      尾崎清和
    • Organizer
      日本毒性病理学会
    • Place of Presentation
      金沢市
    • Year and Date
      2010-02-04
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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