| Project/Area Number |
20580334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
|
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
OGAWA KENJI The Institute of Physical and Chemical Research, 分子リガンド探索研究チーム, 専任研究員 (50251418)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Activin A / TGF-β / Bリンパ球 / マクロファージ / IgA / MMP-9 / Toll-like receptors / アクチビンA / TGF-b1 / MMP-2 |
|---|
| Research Abstract |
In order to determine the roles of the TGF-β superfamily proteins in allergic inflammation, we studied the effects of activin A and TGF-β1 in mouse macrophages and B lymphocytes. Production of activin A was increased, while the expression of TGF-β1 was decreased in macrophages upon activation. Pretreatment with activin A significantly increased IgG, but not IgA and IgM, production, while TGF-β1 significantly enhanced IgA and suppressed IgM production in B cells. The functions of activin A partly overlap but are clearly distinct from that of TGF-β1 in macrophages and B cells, indicating that these two factors have distinct functions in allergic inflammation.
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