| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Reelin is secreted by Cajal-Retzius cells and regulates radial migration of projection neurons in the developing cerebral cortex by inducing tyrosine phosphorylation of an intracellular adaptor protein, Dab1. During the period of this grant, I established a suitable system for analyzing Reelin signaling in vivo based on in utero electroporation with exogenous Dab1 genes into the Dab1-deficient cerebral cortices. Using this system I determined relative importance of the phosphotyrosines of Dab1 to the transmission of Reelin signaling, and I found a possibility that Dab1 may function as a transcription factor to transmit Reelin signaling.
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