Functional analysis of Dab1as a transcription factor for transmission of Reelin signaling
| Project/Area Number |
20580335
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MORIMURA Toshifumi The Institute of Physical and Chemical Research, 神経研究所 疾病研究第二部, 流動研究員 (20333338)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Masaharu 理化学研究所, 脳化学総合研究センター, ユニットリーダー (50111951)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Reelin / Dab1 / Srcファミリーチロシンキナーゼ / チロシンリン酸化 / 投射ニューロン / 放射状移動 / 大脳皮質 / 転写因子 / in utero electroporation / migration / Dabl / Srcファミイーチロシンキナーゼ / チロシンリン酸 |
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| Research Abstract |
Reelin is secreted by Cajal-Retzius cells and regulates radial migration of projection neurons in the developing cerebral cortex by inducing tyrosine phosphorylation of an intracellular adaptor protein, Dab1. During the period of this grant, I established a suitable system for analyzing Reelin signaling in vivo based on in utero electroporation with exogenous Dab1 genes into the Dab1-deficient cerebral cortices. Using this system I determined relative importance of the phosphotyrosines of Dab1 to the transmission of Reelin signaling, and I found a possibility that Dab1 may function as a transcription factor to transmit Reelin signaling.
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Report
(4 results)
Research Products
(8 results)
