| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Genomic DNAs of two S. suis virulent strains belonging two genetically different clones were subtracted by a genomic DNA of an avirulent strain. Twenty-three genes selected were found to exist in only virulent strains. These genes were knocked out via single-cross over, and one of the mutants showed remarkable loss of virulence. However, virulence of the knock out mutant via double-cross over was the same as its parent stain.
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