Expression analyses of canine UCP3 and development of a novel method for treatment of obesity in dogs.
| Project/Area Number |
20580358
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
ISHIOKA Katsumi Nippon Veterinary and Life Science University, 獣医学部・獣医保健看護学科, 准教授 (60409258)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 内科 / 肥満 / イヌ / 骨格筋 / UCP3 / 不飽和脂肪酸 |
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| Research Abstract |
Cell line developed from a canine tumor was proved to be myosarcoma and named "Canine Myogenic Sarcoma (CMS)" because cytokeratin, vimentin and desmin were positive, and MyoD1, myogenin and UCP3 mRNAs were expressed. When we cultured these cells with oleic acid, UCP3 expression was increased. UCP3 disseminates excess energy to heat, then it was suggested that oleic acid is effective for diet therapy of canine obesity.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Establishment and characterization of canine rhabdomyosarcoma cell line, CMS-C.2011
Author(s)
Azakami D., Shibutani H., Dohi M., Takasaki M., Ishioka K., Mori A., Momota Y., Bonkobara M., Washizu T., Michishita M., Hatakeyama H., Ogasawara S., Sako T.
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Journal Title
Journal of Veterinary Medical Science (印刷中)
NAID
Related Report
Peer Reviewed
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