| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The TREX complex has an essential function in mRNA biogenesis. Here I have studied the function of UAP56 and URH49, whish are the component of the TREX complex, in view of the relationship between mRNA biogenesis and genome stability. Fragmentation from chromosome DNA was observed when URH49 was knocked down rather than that UAP56 was. This phenotype was rescued by the forced expression of URH49, RNaseH, SF2 or RNPS1. These results suggest that the TREX complex functions to regulate the interaction of nascent RNA with genomic DNA to prevent the genome instability.
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