Study of encephalopathy inducing constituent in Pleurocybella porrigens

• Project/Area Number: 20590004
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: OHTA Tomihisa Kanazawa University, 薬学系, 教授 (50108560)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 生物活性物質 / スギヒラタケ / 脳症 / ペプチドグリカン / スフィンゴ糖脂質 / 担子菌

Research Abstract

This study was focused on the supposition that Angel Wing (Pleurocybella porrigens) brain disorder was based on plural toxic causes. The refinement and the structural analysis of the peptidyl polysialic analogues having internal organs disorder characteristics and inflammatory nature showed that N-glycolyl neuraminic acid (NeuGc) indicating the antigenicity was specifically included in the glycoprotein of the Angel Wing. On the other hand, the structure of sphingoglycolipid A was determined and synthesized. Sphingoglycolipid A was presumed on impaired characteristics to the nervous system and intestinal epithelia.

Research Products

• [Journal Article] (2009)
  • Author(s): T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugid, F.Takano, T.Ohta
  • Journal Title: J.Health Science 55 Pages: 373-379
  • Peer Reviewed
• [Journal Article] Isolation of N-acetyhlneuraminic acid and N-glycolylneuraminic acid from Pleurocybella porrigens (2009)
  • Author(s): T.Takata, T.Hasegawa, T.Tatsuno, J.Date, Y.Ishigaki, Y.Nakamura, N.Tomosugid, F.Takano, T.Ohta
  • Journal Title: J.Health Science 55(3) Pages: 373-379
  • Peer Reviewed
• [Presentation] N-glycoryl neuraminic acid from edible/toxic mushroom Pleurocybella porrigens (2008)
  • Author(s): J.Date, T.Takata, T.Tatsuno, Y.Ishigaki, F.Takano, T.Ohta
  • Organizer: The 4^<th> ASP-JSP-CCTNM Joint Symposium on Pharmacognosy
  • Place of Presentation: KAIST(Kore)
  • Year and Date: 2008-06-18
• [Presentation] N-glycoryl neuraminic acid from edible/toxic mushroom pleurocy bella porrigens (2008)
  • Author(s): J. Date, T. Takata, T. Tatsuno, Y. Ishigaki. F. Takano, T. Ohta
  • Organizer: The 4^<th> KSP-JSP-CCTNM Joint Symposium on Pharmacognosy, 2008
  • Place of Presentation: Gangneung, Korea
  • Year and Date: 2008-06-18