Study of encephalopathy inducing constituent in Pleurocybella porrigens

Research Project

Project/Area Number	20590004
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Chemical pharmacy
Research Institution	Kanazawa University
Principal Investigator	OHTA Tomihisa Kanazawa University, 薬学系, 教授 (50108560)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	生物活性物質 / スギヒラタケ / 脳症 / ペプチドグリカン / スフィンゴ糖脂質 / 担子菌
Research Abstract	This study was focused on the supposition that Angel Wing (Pleurocybella porrigens) brain disorder was based on plural toxic causes. The refinement and the structural analysis of the peptidyl polysialic analogues having internal organs disorder characteristics and inflammatory nature showed that N-glycolyl neuraminic acid (NeuGc) indicating the antigenicity was specifically included in the glycoprotein of the Angel Wing. On the other hand, the structure of sphingoglycolipid A was determined and synthesized. Sphingoglycolipid A was presumed on impaired characteristics to the nervous system and intestinal epithelia.

Report

(4 results)