| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Recently, there is a tremendous amount of preparation of selenium-containing compounds because of not only interesting reactivity but also biological activity. In this study, we have developed novel selenating reagent prepared by the reaction of potassium p-methylselenobenzoate with 2-bromoethyl-trimethylsilane. Novel selenium-containing β-lactams were efficiently prepared by the reaction of alkenes and alkynes with Grubbs 2^<nd> gen. catalyst. And also the β-lactams were obtained via the regioselective iodocyclization reaction from corresponding alkyne- and alkane-selenoureas. The synthesis of higher-membered selenium heterocycles such as seven- and eight-membered selenium-containing heterocycles has hardly been reported yet.
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