| Project/Area Number |
20590010
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba Institute of Science |
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Principal Investigator |
TAKASAKI Midori Chiba Institute of Science, 薬学部, 准教授 (10179434)
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| Co-Investigator(Kenkyū-buntansha) |
KONOSHIMA Takao 千葉科学大学, 薬学部, 教授 (80121557)
TOKUDA Harukuni 京都府立医科大学, 医学部, 助教 (60111960)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 発がん予防 / 生活習慣病 / 漢方方剤 / Epstein-Barr virus / 生薬単味エキス / 香辛料 |
|---|
| Research Abstract |
In our ongoing studies of anti-tumor promoters from natural products, we have examined a number of chinese medicinal plants, kampo-prescriptions and natural alternative sweeteners. In these experiments, the conventional primary screening test on the inhibitory effects of Epstein-Barr virus early antigen (EBV-EA) induction using Raji cells as an indicator cell and TPA as a promoter have been carried out. More than four hundred crude extracts of Chinese herbal medicines were tested, and seven extracts exhibited the significant inhibitory effects on EBV-EA activation. Of these samples, Eriocaulon buergerianum(gu jing cao), Nelumbo nucifera(lian fang)and stevioside exhibited the remarkable chemopreventive effects on mouse skin two-stage carcinogenesis test. These results strongly suggested the possibility of the crude drugs and kampo medicines on the prevention of chemical carcinogenesis.
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