Hypoglycemic Effects of Compounds from Crude Drugs focused on the participation of Monoamine Neurotransmitters in Blood Glucose Regulation
Project/Area Number |
20590011
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Showa University |
Principal Investigator |
HORI Yumiko Showa University, 薬学部, 講師 (60317584)
|
Co-Investigator(Kenkyū-buntansha) |
TORIIZUKA Kazuo 昭和大学, 薬学部, 教授 (60135035)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 生姜 / 乾姜 / スルホン化誘導体 / 血糖値 / 神経伝達物質 / 血糖調節機構 |
Research Abstract |
The sulfonated derivatives from Shokyo and Kankyo have a glucose-lowering effect on loading sugar, which may be based on inhibition of the activity of saccharide hydrolyzing enzyme. Also, the repeated administration of 6-gingesulfonic acid for five weeks showed continuous hypoglycemic effects throughout the experimental periods in KK-A^y mice. Concomitantly, the hypoglycemic effects of 6-GS were correlated with the increased brain serotonin levels. These findings suggest that serum glucose concentrations influence on the brain monoamine neurotransmitters metabolism in KK-A^y mice.
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Report
(4 results)
Research Products
(6 results)