| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
The sulfonated derivatives from Shokyo and Kankyo have a glucose-lowering effect on loading sugar, which may be based on inhibition of the activity of saccharide hydrolyzing enzyme. Also, the repeated administration of 6-gingesulfonic acid for five weeks showed continuous hypoglycemic effects throughout the experimental periods in KK-A^y mice. Concomitantly, the hypoglycemic effects of 6-GS were correlated with the increased brain serotonin levels. These findings suggest that serum glucose concentrations influence on the brain monoamine neurotransmitters metabolism in KK-A^y mice.
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