| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
There have been various kinds of indole and isoquinoline alkaloids which have intense bioactivity. Although it has been known for several cases that enantiomeric isomers have different bioactivities, there are no general synthetic method that is useful for the selective synthesis of both enantiomers. We have been studying the development of asymmetric synthesis of both enantiomers of alkaloids by the use of organocatalysts and organocopper reagents, and found several asymmetric addition reactions to isoquinoline and b-carboline moieties. these reaction products were applied to the asymmetric synthesis of several bioactive alkaloids. The reaction was also used for the preparation of schulzeine A and penasulfate A, both of which are marine alkaloids having a-glucosidase inhibitory activity.
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