Reaction of unprotected amino acids with aldehydes : New synthetic method for stereoselective 1,2-aminoalchol.
| Project/Area Number |
20590014
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
YOKOYAMA Yuusaku Toho University, 薬学部, 教授 (10095325)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 有機合成 / 無保護アミノ酸 / 脱炭酸 / オキサゾリジン / 1,2-アミノアルコール / 赤堀反応 / 水溶液 / 炭素-炭素結合形成反応 / アミノアルコール / 不斉合成 / N-メチルアミノ酸 / アルドール縮合 / エピネフリン / N-メチルグリシン / シネフリン |
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| Research Abstract |
We succeeded the development of new synthetic method for 1,2-aminoalcohol by the reaction of unprotected amino acids with aldehyde through carbanion, which was formed by the decarboxylation of amino acids.
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Report
(4 results)
Research Products
(64 results)
