Development of new antifungal drugs isolated from fungal sources in order to overcome of deep-seated mycosis
| Project/Area Number |
20590017
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hoshi University |
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Principal Investigator |
KAWAI Kenichi Hoshi University, 薬学部, 教授 (30061295)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOE Tomoo 星薬科大学, 薬学部, 准教授 (10287849)
ITABASHI Taeshi 星薬科大学, 薬学部, 助手 (20350225)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 抗真菌剤 / 深在性真菌症 / 新規分離真菌 / 真菌 |
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| Research Abstract |
The new antifungal drugs will be expected, in consideration of the recent slightly increasing of the deep-seated mycoses. The extracts of newly isolated fungal strains, which had the antifungal activities, were purified by various chromatography and then about 20 new compounds were isolated and determined their structures. The possibility of the antifungal drugs for the above compounds will be tested.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] A new indoloditerpene derivative, penijanthine A, from Penicillium janthinellum2009
Author(s)
Takeshi Itabashi, Tomoo Hosoe, Daigo Wakana, Kazutaka Fukushima, Kayoko Takizawa, Takashi Yaguchi, Kaoru Okada, Galba Maria de Campos Takaki, Ken-ichi Kawai
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Journal Title
J.Natural Med. 63(1)
Pages: 96-99
Related Report
Peer Reviewed
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