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Development of new antifungal drugs isolated from fungal sources in order to overcome of deep-seated mycosis

Research Project

Project/Area Number 20590017
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionHoshi University

Principal Investigator

KAWAI Kenichi  Hoshi University, 薬学部, 教授 (30061295)

Co-Investigator(Kenkyū-buntansha) HOSOE Tomoo  星薬科大学, 薬学部, 准教授 (10287849)
ITABASHI Taeshi  星薬科大学, 薬学部, 助手 (20350225)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords抗真菌剤 / 深在性真菌症 / 新規分離真菌 / 真菌
Research Abstract

The new antifungal drugs will be expected, in consideration of the recent slightly increasing of the deep-seated mycoses. The extracts of newly isolated fungal strains, which had the antifungal activities, were purified by various chromatography and then about 20 new compounds were isolated and determined their structures. The possibility of the antifungal drugs for the above compounds will be tested.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (27 results)

All 2011 2010 2009 2008

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (19 results)

  • [Journal Article] A new antifungal yellow pigment from Aspergillus nishimurae2011

    • Author(s)
      Tomoo Hosoe, Nobuaki Mori, Kumi Kamano, Takeshi Itabashi, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      J.Antibiotics 64(2)

      Pages: 211-212

    • NAID

      10030638179

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A New Antifungal Yellow Pigment from Aspergillus nishimurae2011

    • Author(s)
      T.Hosoe, N.Mori, et al.
    • Journal Title

      J.Antibiotics

      Volume: 64 Pages: 211-212

    • NAID

      10030638179

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novofumigatamide, new cyclic tripeptide from Aspergillus novofumigatus2010

    • Author(s)
      Kazuki Ishikawa, Tomoo Hosoe, Takeshi Itabashi, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      Heterocycles 81(9)

      Pages: 2143-2148

    • NAID

      40017252394

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novoamauromine and ent-cycloechinulin : Two new diketopiperazine derivatives from Aspergillus novofumigatus2010

    • Author(s)
      Kazuki Ishikawa, Tomoo Hosoe, Takeshi Itabashi, Daigo Wakana, Kayoko Takizawa, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      Chem.Pharm.Bull. 58(5)

      Pages: 717-719

    • NAID

      130000255834

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Novofumigatamide, New Cyclic Tripeptide from Aspergillus novofumigatus2010

    • Author(s)
      K.Ishikawa, T.Hosoe, et al.
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 2143-2148

    • NAID

      40017252394

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novoamauromine and ent-Cycloechinulin : Two New Di-ketopiperazine Derivatives from Aspergillus novofumi-gatus2010

    • Author(s)
      K.Ishikawa, T.Hosoe, T.Itabashi, D.Wakana, K.Takizawa, et al.
    • Journal Title

      Chem.Pharm.Bull. 58

      Pages: 717-719

    • NAID

      130000255834

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cytotoxic and antifungal activity of two new sesquiterpenes, malfilanol A and B, derived from Malbranchea filamentosa2009

    • Author(s)
      Daigo Wakana, Tomoo Hosoe, Hiroshi Wachi, Takeshi Itabashi, Kazutaka Fukushima, Takashi Yaguchi, Ken-ichi Kawai
    • Journal Title

      J.Antibiotics 62(4)

      Pages: 217-219

    • NAID

      10030635065

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A new indoloditerpene derivative, penijanthine A, from Penicillium janthinellum2009

    • Author(s)
      Takeshi Itabashi, Tomoo Hosoe, Daigo Wakana, Kazutaka Fukushima, Kayoko Takizawa, Takashi Yaguchi, Kaoru Okada, Galba Maria de Campos Takaki, Ken-ichi Kawai
    • Journal Title

      J.Natural Med. 63(1)

      Pages: 96-99

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Presentation] Aspergillus novofumigatus CBS117520から単離された新規環状テトラペプチドおよびメロテルペノイド2011

    • Author(s)
      石川和樹、板橋武史、細江智夫、滝澤香代子、矢口貴志、福島和貴、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Neosartorya sp.A159株の産生する新規meroterpeneおよびbenzodiazepine誘導体2011

    • Author(s)
      板橋武史、細江智夫、滝澤香代子、矢口貴志、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Emericella sp.IFM57991より得られた新規farnesylisobenzofurane誘導体2011

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、滝澤香代子、矢口貴志、福島和貴、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Beauveria bassiana IFM59745株の成分検索2011

    • Author(s)
      森本重輝、齊藤哲也、石川和樹、板橋武史、細江智夫、滝澤香代子、矢口貴志、河合賢一
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Emericella sp.IFM57991より得られた新規isobenzofuranおよびisobenzofuranone誘導体 第2号2010

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、河合賢一、滝澤香代子、矢口貴志、福島和貴
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report
  • [Presentation] Aspergillus novofumigatusから単離された新規メロテルペノイド2010

    • Author(s)
      石川和樹、細江智夫、板橋武史、河合賢一、滝澤香代子。矢口貴志、福島和貴
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Neosartorya sp. A159株の産生するジケトピペラジン化合物の立体化学2010

    • Author(s)
      板橋武史、細江智夫, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Aspergillus novofumigatusより得られる新規環状ペプチド及びベンゾジアゼピン誘導体の構造2009

    • Author(s)
      石川和樹、板橋武史、細江智夫、河合賢一、滝澤香代子、矢口貴志、福島和貴、若菜大悟、合田幸広
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Emericella sp.IFM57991より得られた新規isobenzofuranおよびisobenzofuranone誘導体2009

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、河合賢一、滝澤香代子、矢口貴志、福島和貴
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-03
    • Related Report
      2010 Final Research Report
  • [Presentation] Emericella sp. IFM57991より得られた新規isobenzofuranおよびisobenzofuranone誘導体2009

    • Author(s)
      齊藤哲也、板橋武史、細江智夫、河合賢一(星薬大)、滝澤香代子, 他
    • Organizer
      日本生薬学会第56回年会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Aspergillus novofumigatusの産生する新規diketopiperazineおよびditerpene誘導体2009

    • Author(s)
      石川和樹、若菜大悟、板橋武史、細江智夫、滝澤香代子。矢口貴志、河合賢一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Neosartorya sp.A159株の産生するジケトピペラジン化合物の立体化学2009

    • Author(s)
      板橋武史、細江智夫、滝澤香代子。矢口貴志、河合賢一
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Zebrafishに対する色素形成抑制作用を指標とした真菌由来"美白効果"物質の探索2009

    • Author(s)
      二宮早也夏、細江智夫、板橋武史、河合賢一、野中里紗、輪千浩史、瀬山義幸、矢口貴志、滝澤香代子、福島和貴
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] Neosartorya sp. A159株の産生するジケトピペラジン化合物の立体化学2009

    • Author(s)
      板橋武史, 細江智夫, 他
    • Organizer
      日本薬学会
    • Place of Presentation
      京都、国際会館
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Aspergillus novofumigatusの産生する新規diketopipera-zineおよびditerpene誘導体2009

    • Author(s)
      石川和樹, 若菜大悟, 他
    • Organizer
      日本薬学会
    • Place of Presentation
      京都、国際会館
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Malbranchea gypseaの成分検索2008

    • Author(s)
      笠原宏之、細江智夫、板橋武史、河合賢一、滝澤香代子、福島和貴
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Malbranchea gypseaの成分検索2008

    • Author(s)
      笠原宏之, 細江智夫, 他
    • Organizer
      日本生薬学会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Neosartorya属菌の"新種"とプロファイルされたA159菌株の成分研究2008

    • Author(s)
      板橋武史、細江智夫、河合賢一、矢口貴志
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-19
    • Related Report
      2010 Final Research Report
  • [Presentation] Malbranchea filamentosaから得られる新規セスキテルペンの構造2008

    • Author(s)
      若菜大悟、細江智夫、板橋武史、矢口貴志、滝澤香代子、福島和貴、河合賢一
    • Organizer
      日本生薬学会第55回年会
    • Place of Presentation
      長崎
    • Year and Date
      2008-09-19
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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