Development of dosage form using elastin fragments by incorporation of β-amino acids
| Project/Area Number |
20590023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences |
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Principal Investigator |
DOI Mitsunobu Osaka University of Pharmaceutical Sciences, 薬学部, 教授 (10183500)
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| Co-Investigator(Kenkyū-buntansha) |
ASANO Akiko 大阪薬科大学, 薬学部, 助教 (40291801)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMAMOTO Daisuke 大阪医科科大学, 医学部, 准教授 (50240106)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 構造活性相関 / βアミノ酸 / CD / 結晶化 / ゲル化 / コアセルベーション / コラーゲン |
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| Research Abstract |
Physicochemical properties of elastin fragment (EF) VAPGVG reflect those of elastin itself. We attempted to incorporations of β-amino acids to EF. In CD spectra, a positive Cotton observed at 220 nm was reversed to negative by incorporation of β-amino acids. This spectrum changes suggested β-amino acids caused the structural change f EF. On the other hand, the PVGVG repeating peptide (PVGVG)_4 shows no typical CD spectrum. The replacement Gly^3 of this 20mer with βGly lead a CD spectrum change indicating a structural formation. Moreover, X-ray analysis of Boc-Pro-Hyp-OMe shows the structural characteristics of this tripeptide resemble to those collagen model peptide.
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Report
(4 results)
Research Products
(6 results)
