Development of effective method for an introduction of decarboxylative nucleophile in the synthesis of indole derivative and its application to solid phase catalytic reaction
| Project/Area Number |
20590024
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
MIKI Yasuyoshi Kinki University, 薬学部, 教授 (40122113)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HAMAMOTO Hiromi 近畿大学, 薬学部, 講師 (40365896)
|
|---|
| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | インドール / ハロゲン化 / 超原子化ヨウ素化合物 / 脱炭酸 / ブロモ化 |
|---|
| Research Abstract |
Reaction of indole-2,3-dicarboxylic acids with hypervalent iodine reagent and lithium halide gave the corresponding 2,3-dihaloindoles via decarboxylative halogenation. Pyrrolophenanthridone alkaloids were also synthesized via decarboxylative halogenation and reduction of the iodo compound. In a similar manner, 4-methoxybenzoic acid derivatives were also converted to 4-iodoanisoles.
|
Report
(4 results)
Research Products
(61 results)
