| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
First total synthesis of neobivsanin B, which have a neurite-elongation activity was achieved. By an analysis of structure activity correlation, the minimum essential structure related to onset of the activity was revealed, and a highly active compound having simple structure was developed. And also a fluorescent probe molecule was synthesized, the behavior of this probe in the PC12 cell line was analyzed.
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