Construction of influenza virosome and its development to preparation of vaccine
| Project/Area Number |
20590033
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Toyama |
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Principal Investigator |
UENO Masaharu University of Toyama, 大学院・医学薬学研究部(薬学), 教授 (40080197)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 製剤学 / インフルエンザ / ビロソーム / 人工膜ワクチン / オレイン酸 / ラフト / HA / NA / 中和抗体 / 皮下投与 / 経鼻投与 / アジュバント / BALF / インフルエンザビロソーム / ウイルス抗原蛋白質 / ELISA / フリーズ・フラクチャー / 電子顕微鏡 |
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| Research Abstract |
Influenza is one of the common infectious diseases caused by influenza virus. Vaccines are the most effective means to fight infectious diseases. Liposomes are known to be effective immunoadjuvants. In this article, we introduced a new method to prepare the liposome vaccine, "influenza virosomes", using inter-membrane protein transfer. We concluded that this method is useful to prepare virosomes. The virosomes showed high immunoactivity especially with MDP derivatives.
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Report
(4 results)
Research Products
(10 results)
