The Development of octabromed porphine immobilized silica gels as a stationary phase for HPLC

• Project/Area Number: 20590035
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Okayama University
• Principal Investigator: MIFUNE Masaki Okayama University, 大学院・医歯薬学総合研究科, 准教授 (00200105)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
• Keywords: 八臭素化ポルフィリン固定化シリカゲル / 多環芳香族炭化水素 / HPLC充填剤 / 無極性移動相 / 極性移動相 / 残存極性基 / アシル化 / シリル化 / 分離の向上 / M-OBTCPP_Dカラム / 中心金属の影響 / 多環性芳香族化合物 / 無極性移動層 / HPLC / 充填剤 / 八臭素金属ポルフィリン固定化シリカゲル / 金属の影響

Research Abstract

It was developed octabromed metal-porphine (M-OBTC) immobilized silica gels as a stationary phase for HPLC using both polar and on-polar mobile phase. Furthermore, Zn-OBTC silica gels gave highest theoretical plate numbers. It was revealed the effect of modification of non-reacted amino and silanol groups and a stationary phase modified decanoyl and tetramethylsilane groups could separate polyaromatic-hydrocarbons in short time. It was expected practical use the column developed here.

Research Products

• [Journal Article] Photometric Study on the reaction between 2,3,7,8,12,13,17,18-Octabromo-5,10,15,20-tetrakis- (4-methyl-pyridyl) porphine and various metal ions (2011)
  • Author(s): M.Mifune, A.Iwado, M.Taniguchi, S.Kamino, S.Enomoto
  • Journal Title: Yakugakuzasshi 131(8),掲載決定
  • NAID: 130001075913
• [Journal Article] Ion-Exchange Resins Modified with Metal-Porphyrin as a Catalysis for Oxidation of Epinephrine (Adrenaline) (2008)
  • Author(s): Kitamura Y., Mifune M., Takatsuki T., Iwasaki T., Kawamoto M., Iwado A., Chikuma M., Saito Y.
  • Journal Title: Catalysis Communications 9(2) Pages: 224-228
• [Presentation] 金属イオン捕集剤としてのoctabromo-tetrakis(p-carboxy)-phenylporphine担持陰イオン交換樹脂の可能性 (2011)
  • Author(s): 御舩正樹、岩藤章正、北村陽二、巽朝菜、神野伸一郎、榎本秀一
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 金属イオン捕集剤としてもoctabromotetrakis(p-carboxypheny1)porphine坦持陰イオン交換樹脂の可能性 (2011)
  • Author(s): 御舩正樹
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 金属-八臭素化ポルフィリン固定化シリカゲルの残存極性基修飾とそのHPLCに及ぼす影響 (2008)
  • Author(s): 清水貴子, 中島由香里, 横山直子, 森勝也, 清水隆也, 北村陽二, 御舩正樹, 斎藤寛
  • Organizer: 第47回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2008-11-09