Design and evaluation of supramolecular system for siRNA delivery having tumor-cell specific, long-circulating and sustained release properties
| Project/Area Number |
20590037
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kumamoto University |
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Principal Investigator |
ARIMA Hidetoshi Kumamoto University, 大学院・生命科学研究部, 教授 (50260964)
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| Co-Investigator(Renkei-kenkyūsha) |
KAI Hirofumi 熊本大学, 大学院・生命科学研究部, 教授 (30194658)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ドラッグデリバリー / siRNA / デンドリマー / シクロデキストリン / 超分子複合体 / 葉酸 / ポリエチレングリコール / ドラッグデリバリーシステム / ターゲッティング / ターゲティング / shRNA / 葉酸レセプター / 癌細胞 |
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| Research Abstract |
The aim of the present study is to design and evaluate novel supramolecular-based drug delivery system having sustained release, long-circulating and tumor-selective properties for siRNA and shRNA, which are known to be an ultimate molecularly-targeted drug. Eventually, these results suggest that PEG-Fol-α-CDE/γ-CyD supramolecular complexes have the potential for novel siRNA delivery system having sustained release, long-circulating and tumor-selective properties.
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Report
(4 results)
Research Products
(42 results)
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[Journal Article] In Vitro and In Vivo Gene Delivery Mediated by Lactosylated Dendrimer/・ -Cyclodextrin Conjugates (G2) into Hepatocytes.2010
Author(s)
H. Arima, S.Yamashita, Y.Mori, Y.Hyashi, K.Motoyama, K.Hattori, T.Takeuchi, H.Jono, Y.Ando, F.Hirayama, K.Uekama
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Journal Title
J. Control. Release Vol.146
Pages: 106-117
Related Report
Peer Reviewed
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[Journal Article] In Vitro and In Vivo Gene Delivery Mediated by Lactosylated Dendrimer/α-Cyclodextrin Conjugates (G2) into Hepatocytes.2010
Author(s)
H.Arima, S.Yamashita, Y.Mori, Y.Hayashi, K.Motoyama, K.Hattori, T.Takeuchi, H.Jono, Y.Ando, F.Hirayama, K.Uekama
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Journal Title
J.Control.Release
Volume: 146
Pages: 106-117
Related Report
Peer Reviewed
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