| Project/Area Number |
20590039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Hokkaido Pharmaceutical University School of Pharmacy |
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Principal Investigator |
MORIMOTO Kazuhiro Hokkaido Pharmaceutical University School of Pharmacy, 薬学部, 教授 (10113135)
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| Co-Investigator(Kenkyū-buntansha) |
CHONO Sumio 北海道薬科大学, 薬学部, 准教授 (90347790)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 感染症 / 呼吸器 / 肺細胞 / DDS / 細胞内寄生菌 |
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| Research Abstract |
For making of treatment system of respiratory infections, (1) distribution of macrolide antibiotics in plasma, lung epithelial lining fluid (ELF) and alveolar macropharges(AMs), (2) efficient drug delivery to ELF and AMs by pulmonary administration of fluoroquinolone antibiotic incorporated into mannosylated or PEGylated liposomes were evaluated. (1) The areas under drug concentration-time curve (AUC) in ELF, following oral administration these antibiotics to rats was higher than AUCs in plasma, AUCs in AMs higher than AUCs in ELF. The high distribution of antibiotics is due to the sustained distributions to ELF via MDRI as well as the high uptakes by AMs themselves via active transport and trapping in organelles. (2) Antibiotic incorporated mannosylated liposomes were delivered to AMs. Antibiotic incorporated PEGylated liposomes highly distributed in ELF without uptakes by AMs.
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