| Project/Area Number |
20590046
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
KOYAMA Junko Kobe Pharmaceutical University, 薬学部, 准教授 (60102109)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Norihiro 神戸薬科大学, 薬学部, 教授 (90205477)
MORITA Izumi 神戸薬科大学, 薬学部, 助手 (20299085)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分析化学 / 生物活性物質 / 酸化還元電位 / フラボノイド / リグナン / 抗アレルギー活性 / LC-MS / KU812細胞 / サイクリックボルタンメトリー / ケミカルメディエーター / EBV-EA活性化抑制試験 / EBV-EA活性化抑制効果 / プロトベルベリン / 第1還元電位 / 抗菌活性 / 細胞毒性 / 電子的性質 |
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| Research Abstract |
The biochemical activities (anti-promoter of tumor, anti-bacterial, anti-inflammatory, and anti-allergic activities) of quinones, flavonoids, lignans, and alkaloids were determined. Good correlation was found between the activities and the oxidation-reduction potentials by a cyclic voltammetry. It was thought that elucidating the generality of these correlations enabled a prediction of the bioactivity of compound by the physical measurement without in vitro assay. As for the result, the oxidation-reduction potential was suggested that it was a good parameter.
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