New miceller agent for antioxidation therapy based on XO inhibition using AHPP
| Project/Area Number |
20590049
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
MAEDA Hiroshi Sojo University, 薬学部, 教授 (90004613)
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| Co-Investigator(Kenkyū-buntansha) |
FAN Jun 崇城大学, 薬学部, 准教授 (20412736)
NAKAMURA Hideaki 崇城大学, 薬学部, 助手 (30435151)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ドラッグデリバリー / XO阻害剤 / 徐放性 / DDS / 降圧剤 / 水可溶化 / NOの寿命延長 / ナノメディシン / PEG化医薬 / NOの寿命 |
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| Research Abstract |
We had previously discovered that AHPP exhibited a potent inhibitory effect against xanthine oxidase (XO). The difficulty to make AHPP as pharmaceutical agent resides in poor water solubility and low MW that has short in vivo t1/2 and no targeting capacity to the diseased site.
To solve these problems we synthesized PEG-conjugate of AHPP and SMA (styrene-co-maleic acid) micelles containing AHPP. As the results, we found (1) XO inhibitory activity in vitro of both polymeric AHPP showed about 80% of that of free AHPP, and satisfactory. (2) In vivo evaluation of ischemia-reperfusion (I/R) model of liver, the polymeric AHPP showed significant effect preventing I/R induced tissue (liver) toxicity. (3) Oral administration of PEG-AHPP in lipid formation in the spontaneously hypertensive rats resulted in lowering of blood pressure to normal range. (4) The antihypertensive effect lasted even more than 24 hr after one oral administration.
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Report
(4 results)
Research Products
(58 results)
