Selective Preparation of Metastable Polymorphs Utilizing Inclusion Complexation with Cyclodextrins
| Project/Area Number |
20590050
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IOHARA Daisuke 崇城大学, 薬学部, 助手 (40454954)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2010: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | シクロデキストリン / 結晶多形 / 準安定結晶 / 晶癖 / 包接複合体 / 溶液媒介性多形転移 / 溶解速度 / 溶出挙動 |
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| Research Abstract |
The selective crystallization of metastable forms and the control of crystal habits were conducted, utilizing inclusion complexations with cyclodextrins (CyDs). (1) Metastable forms of chlorpropamide were deposited from aqueous 2-hydroxy- butyl-β-CyD solutions, i.e. the metastable form II of the drug from lower CyD concentrations, whereas the most labile form III from higher CyD concentrations. (2) The crystal shape of aspirin was changed from plate to needle crystals, when the crystallizing solvent was changed from water to aqueous 2-hydroxybutyl-β-CyD solutions. The results indicate that 2-hydroxybutyl-β-CyD is useful for preparation of metastable forms and control of crystal habit of solid drugs.
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Report
(4 results)
Research Products
(28 results)
