The identification and characterization of proteins that are S-nitrosylated during bacterial infection and sepsis
| Project/Area Number |
20590052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIYA Tadashi Hokkaido University, 大学院・医学研究科, 講師 (80399831)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | iNOS / SPSB / ユビキチン化 / 蛋白質分解 / 敗血症 / ubiquitination / SSB / S-ニトロシル化 |
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| Research Abstract |
We have identified SPSB family of proteins as an iNOS-binding protein. SPSB family of proteins function as an adaptor protein that bridges between iNOS and the Elongin B/C-Cul5-type E3 ubiquitin ligase, and induce the ubiquitin/proteasome-dependent degradation of iNOS. SPSB family of proteins play an essential role in protection against the cytotoxic effect of iNOS.
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Report
(4 results)
Research Products
(16 results)
