Roles of Collgenase-3/MMP13 for Collagenolysis in On-set Osteoporosis
Project/Area Number |
20590053
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Tokyo University of Agriculture and Technology |
Principal Investigator |
INADA Masaki Tokyo University of Agriculture and Technology, 大学院・工学研究院, 准教授 (80401454)
|
Co-Investigator(Renkei-kenkyūsha) |
MIYAURA Chisato 東京農工大学, 大学院・工学研究院, 教授 (20138382)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 骨粗鬆症 / 病態生理学 / マトリックス / コラーゲン / 病態生化学 / 3型コラゲナーゼ / 骨吸収 / 骨形成 / 遺伝子欠損マウス / プロスタグランジンE / 癌の骨転移 / がんの肺転移 / 固形腫瘍 / がん / 骨代謝 |
Research Abstract |
This proposal investigated roles of bone cell expressed collagenase 3 on bone remodeling and its related diseases using MMP13 gene deficient mice (MMP13KO). In the mouse models of osteoporosis, the result indicates suppressive phenotypes of bone resorption in MMP13KO.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Pyrroloquinoline quinone inhibits the fibrillation of amyloid proteins.2010
Author(s)
Kim J, Kobayashi M, Fukuda M, Ogasawara D, Kobayashi N, Han S, Nakamura C, Inada M, Miyaura C, Ikebukuro K, Sode K
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Journal Title
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Peer Reviewed
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[Presentation] Carborane BE360, one of the carbon-containing polyhedral boron-cluster compounds, is a new type of selective estrogen receptor modulator.2008
Author(s)
Inada M, Tominari T, Hirata M, Matsumoto C, Takita M, Endo Y, Miyaura C
Organizer
American Society of Bone and Mineral Research
Place of Presentation
Montreal, Quebec, Canada
Year and Date
2008-09-12
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