| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
This study has aimed to clarify the molecular function of a novel nematode RNAi factor DRH-3 that was originally found in my previous work. In this study, I successfully identified a novel E1 protein that interacts with DRH-3 by comprehensive yeast two-hybrid analyses, suggesting that DRH-3 likely functions in the RNAi pathway by interacting with E1 protein in C. elegans. Thus, E1 protein could be an important clue to clarify the molecular mechanism of the DRH-3-containing protein complex. In addition, the expression profile analyses suggested that DRH-3 localizes in particular cellular domains and plays a role in germ-line formation.
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