Regulation of the onset of atopic asthma-like phenotype by microorganisms (virus-mimetics)
Project/Area Number |
20590062
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Gifu Pharmaceutical University |
Principal Investigator |
TANAKA Hiroyuki Gifu Pharmaceutical University, 薬学部, 准教授 (70264695)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | アレルギー / 気管支喘息 / ウィルス / 微生物 / 自然免疫応答 / ウィルス感染 |
Research Abstract |
In the present study, we examined the effect of intratracheal administration of double-stranded RNA (dsRNA), produced during virus replication, prior to the repeated instillation of mite extract into the airways on the development of asthma-like phenotypes by in mice. As a result, a lower amount of dsRNA augmented the onset of asthma-like phenotypes, whereas a higher dose of dsRNA inhibited the development of the pathophysiological changes. These effects by dsRNA are dependent of CD8+T cells and IL-13 or CD8+T cells and IFN-g, respectively. Furthermore, we demonstrated that these modifications by dsRNA were not dependent on TLR3, TLR4 or MDA-5.
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Report
(4 results)
Research Products
(27 results)