| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
In the present study, we examined the effect of intratracheal administration of double-stranded RNA (dsRNA), produced during virus replication, prior to the repeated instillation of mite extract into the airways on the development of asthma-like phenotypes by in mice. As a result, a lower amount of dsRNA augmented the onset of asthma-like phenotypes, whereas a higher dose of dsRNA inhibited the development of the pathophysiological changes. These effects by dsRNA are dependent of CD8+T cells and IL-13 or CD8+T cells and IFN-g, respectively. Furthermore, we demonstrated that these modifications by dsRNA were not dependent on TLR3, TLR4 or MDA-5.
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