Regulatory mechanism of the induction and function of IL-1

• Project/Area Number: 20590064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: ONOZAKI Kikuo Nagoya City University, 大学院・薬学研究科, 教授 (20101313)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IL-1 / 化学物質 / タバコ / 関節リウマチ / 炎症性サイトカイン / 性ホルモン / 自己免疫

Research Abstract

(1) The mechanism of constitutive production of IL-1α : For the constitutive production of IL-1α in human melanoma cells down-regulation of HDAC1 activity and up-regulation of Sp1 activity appeared to be important. (2) Regulation of IL-1 function by sex hormone : Dihydrotestosterone inhibited the proinflammatory cytokine production in human synovial fibroblast cells through hormone receptor-mediated down-regulation of NF-κB activity. (3) Regulation of IL-1 production by chemicals : Cigarette smoke condensate induced proinflammatory cytokines from RA patient-derived synovial cells, and augmented the development of collagen-induced arthritis in mice.

Research Products

• [Journal Article] Etiological role of cigarette smoking in rheumatoid arthritis : Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice. (2011)
  • Author(s): Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
  • Journal Title: Biochem Biophys Res Commun. 404(4) Pages: 1088-1092
• [Journal Article] Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. (2011)
  • Author(s): Horita Y, Takii T, Kuroishi R, Chiba T, Ogawa K, Kremer L, Sato Y, Lee Y, Hasegawa T, Onozaki K.
  • Journal Title: Bioorg Med Chem Lett. 21(3) Pages: 899-903
• [Journal Article] Etiological role of cigarette smoking in rheumatoid arthritis : Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in mice. (2011)
  • Author(s): Okamoto S, Adachi M, Chujo S, Yamada K, Akita K, Itoh S, Takii T, Hayakawa K, Onozaki K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 404(4) Pages: 1088-92
  • Peer Reviewed
• [Journal Article] Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivatives. (2011)
  • Author(s): Horita Y, 他9名中10番目
  • Journal Title: Bioorg Med Chem Lett. Volume: 21(3) Pages: 899-903
  • Peer Reviewed
• [Journal Article] Interleukin 1(IL-1) alpha, beta, IL-1受容体とIL-1受容体アンタゴニスト (2011)
  • Author(s): 林秀敏、小野嵜菊夫
  • Journal Title: 日本臨床 Volume: 68 Pages: 662-66
• [Journal Article] Effectiveness of BCG vaccination to aged mice (2010)
  • Author(s): Ito T, Takii T, Mitsuo Maruyama M, Daisuke Hayashi D, Takeshi Wako T, Azusa Asai A, Yasuhiro, Horita Y, Taniguchi K, Yano I, Yamamoto S, Onozaki K
  • Journal Title: Immunity & Ageing 7 Pages: 12-15
• [Journal Article] Cigarette smoke condensate extracts augment collagen-induced arthritis in mice. (2010)
  • Author(s): Chujo S, Okamoto S, Sunahara R, Adachi M, Yamada K, Hayashi H, Taakii T, Hayakawa K, Onozaki K
  • Journal Title: Int Immunopharmacol. 10(10) Pages: 1194-1199
• [Journal Article] Dual mode of regulation of cell division cycle 25 A protein by TRB3. (2010)
  • Author(s): Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.
  • Journal Title: Biol Pharm Bull. 33(7) Pages: 1112-1116
  • NAID: 130000300272
• [Journal Article] Biochemical characteristics among Mycobacterium bovis BCG substrains. (2010)
  • Author(s): Hayashi D, Takii T, Mukai T, Makino M, Yasuda E, Horita Y, Yamamoto R, Fujiwara A, Kanai K, Kondo M, Kawarazaki A, Yano I, Yamamoto S, Onozaki K
  • Journal Title: FEMS Microbiol Lett. 306(2) Pages: 103-109
• [Journal Article] Halophilic beta-lactama as a new solubility-and folding-enhancing tag protein : production of native human interleukin 1 alpha and human neutrophil alpha-defensin. (2010)
  • Author(s): Tokunaga H, Saito S, Sakai K, Yamaguchi R, Katsuyama I, Arakawa T, Onozaki K Arakawa T, Tokunaga M.
  • Journal Title: Appl Microbiol Biotechnol. 86(2) Pages: 649-658
• [Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375. (2010)
  • Author(s): Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K
  • Journal Title: Biochem Biophys Res Commun. 392(3) Pages: 369-372
• [Journal Article] Anaphase-promoting complex/cyclosomecdh 1 mediates the ubiquitination and degradation of TRB3. (2010)
  • Author(s): Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
  • Journal Title: Biochem Biophys Res Commun. 92(3) Pages: 289-294
• [Journal Article] Staphylococcal superantigen-like protein 10 (SSL10) binds to human immune-Globulin G(IgG) and inhibits complement activation via the classical pathway. (2010)
  • Author(s): Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
  • Journal Title: Mol Immunol. 47(4) Pages: 932-938
• [Journal Article] Dual mode of regulation of cell division cycle 25 A protein by TRB3. (2010)
  • Author(s): Sakai S, Ohoka N, Onozaki K, Kitagawa M, Nakanishi M, Hayashi H.
  • Journal Title: Biol Pharm Bull. Volume: 33(7) Pages: 1112-6
  • NAID: 130000300272
  • Peer Reviewed
• [Journal Article] Effectiveness of BCG vaccination to aged mice (2010)
  • Author(s): Ito T., 他12名中13番目
  • Journal Title: Immunity & Ageing Volume: 7 Pages: 12-15
  • Peer Reviewed
• [Journal Article] Cigarette smoke condensate extracts augment collagen-induced arthritis in mice. (2010)
  • Author(s): Chujo S, 他8名中9番目
  • Journal Title: Int Immunopharmacol. Volume: 33(7) Pages: 1112-6
  • Peer Reviewed
• [Journal Article] Biochemical characteritics among Mycobacterium bovis BCG substrains. (2010)
  • Author(s): Hayashi D, 他13名中14番目
  • Journal Title: FEMS Microbiol Lett. Volume: 306(2) Pages: 103-9
  • Peer Reviewed
• [Journal Article] Halophilic beta-lactamase as a new solubility- and folding-enhancing tag protein : production of native human interleukin lalpha and human neutrophil alpha-defensin. (2010)
  • Author(s): Tokunaga H, 他8名中7番目
  • Journal Title: Appl Microbiol Biotechnol. Volume: 86(2) Pages: 649-658
  • Peer Reviewed
• [Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375. (2010)
  • Author(s): Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K.
  • Journal Title: Biochem Biophys Res Commun. Volume: 392(3) Pages: 369-372
  • Peer Reviewed
• [Journal Article] Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3. (2010)
  • Author(s): Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 392(3) Pages: 289-294
  • Peer Reviewed
• [Journal Article] Staphylococcal superantigen-like protein 10(SSL10) binds to human immunoglobulin G(IgG) and inhibits complement activation via the classical pathway. (2010)
  • Author(s): Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T.
  • Journal Title: Mol Immunol. Volume: 47(4) Pages: 932-8
  • Peer Reviewed
• [Journal Article] Etiological and biological aspects of cigarette smoking in rheumatoid arthritis. (2009)
  • Author(s): Onozaki K.
  • Journal Title: Inflamm Allergy Drug Targets. 8(5) Pages: 364-368
• [Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis (2009)
  • Author(s): Horita Y, Takii T, Chiba T, Kuroishi R, Maeda Y, Kurono Y, Inagaki E, Nishimura K, Yamamoto Y, Abe C, Mori M, Onozaki K.
  • Journal Title: Bioorg Med Chem Lett. 15;19(22) Pages: 6313-6316
• [Journal Article] An environmental sensor, TRPV4 is a novel regulator of intracellular Ca^<2+> in human, synoviocytes. (2009)
  • Author(s): Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.
  • Journal Title: Am J Physiol Cell Physiol. 297(5)
• [Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains. (2009)
  • Author(s): Hayashi D, Takii T, Fujiwara N, Fujita Y, Yano I, Yamamoto S, Kondo M, Yasuda E, Inagaki E, Kanai K, Fujiwara A, Kawarazaki A, Chiba T, Onozaki K.
  • Journal Title: FEMS Immunol Med Microbiol. 56(2) Pages: 116-128
• [Journal Article] Population is a Critical Factor for Global Carbon Dioxide Increase. (2009)
  • Author(s): Onozaki K
  • Journal Title: J. Health Sci. 55(1) Pages: 125-127
  • NAID: 110007055902
• [Journal Article] Population is a Critical Factor for Global Carbon Dioxide Increase (2009)
  • Author(s): Onozaki K
  • Journal Title: J Health Sci 55(1) Pages: 125-127
  • NAID: 110007055902
  • Peer Reviewed
• [Journal Article] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin(BCG)substrains (2009)
  • Author(s): Hayashi D, 他13名中の14番目
  • Journal Title: FEMS Immunol Med Microbiol 56(2) Pages: 116-128
  • Peer Reviewed
• [Journal Article] An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes (2009)
  • Author(s): Itoh Y, Hatano N, Hayashi H, Onozaki K, Miyazawa K, Muraki K.
  • Journal Title: Am J Physiol Cell Physiol 297(5)
  • Peer Reviewed
• [Journal Article] Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosis (2009)
  • Author(s): Horita Y, 他11名中の12番目
  • Journal Title: Bioorg Med Chem Lett 19(22) Pages: 6313-6316
  • Peer Reviewed
• [Journal Article] Etiological and biological aspects of cigarette smoking in rheumatoid arthritis (2009)
  • Author(s): Onozaki K
  • Journal Title: Inflamm Allergy Drug Targets 8(5) Pages: 364-368
  • Peer Reviewed
• [Journal Article] Staphylococcal superantigen-like protein 10(SSL10)binds to human immunoglobulin G(IgG)and inhibits complement activation via the classical pathway (2009)
  • Author(s): Itoh S, Hamada E, Kamoshida G, Yokoyama R, Takii T, Onozaki K, Tsuji T
  • Journal Title: Mol Immunol 74(4) Pages: 932-938
  • Peer Reviewed
• [Journal Article] Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3 (2009)
  • Author(s): Ohoka N, Sakai S, Onozaki K, Nakanishi M, Hayashi H
  • Journal Title: Biochem Biophys Res Commun 392(3) Pages: 289-294
  • Peer Reviewed
• [Journal Article] IL-1-induced ERK1/2 activation up-regulates p21(Wafl/Cip1)protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375 (2009)
  • Author(s): Arakawa T, Hayashi H, Itoh S, Takii T, Onozaki K
  • Journal Title: Biochem Biophys Res Commun 392(3) Pages: 369-372
  • Peer Reviewed
• [Journal Article] Halophilic beta-lactamase as a new solubility- and folding-enhancing tag protein : production of native human interleukin 1alpha and human neutrophil alpha-defensin (2009)
  • Author(s): Tokunaga H, 他9名中の7番目
  • Journal Title: Appl Microbiol Biotechnol 86(2) Pages: 649-658
  • Peer Reviewed
• [Journal Article] Inhibition of Human Immunodeficiency Virus Type 1 Replication by Blocking I{kappa}B Kinase with Noraristeromycin. (2008)
  • Author(s): Asamitsu K, Yamaguchi T, Nakata K, Hibi Y, Victoriano AF, Imai K, Onozaki K, Kitade Y, Okamoto T.
  • Journal Title: J.Biochem. 144(5) Pages: 581-589
• [Journal Article] Cigarette smoke condensate up-regulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte line. (2008)
  • Author(s): Shizu M, Itoh Y, Sunahara R, Chujo S, Hayashi H, Ide Y, Takii T, Koshiko M, Chung SW, Hayakawa K, Miyazawa K, Hirose K, Onozaki K.
  • Journal Title: J.Interferon Cytokine Res. 28 Pages: 509-522
• [Journal Article] Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375. (2008)
  • Author(s): Arakawa T, Yamamura T, Hattori T, Hayashi H, Mori A, Yoshida A, Uchida C, Kitagawa M, Onozaki K.
  • Journal Title: Int Immunopharmacol. 8(1) Pages: 80-89
• [Journal Article] The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1α in human melanoma cells. (2008)
  • Author(s): Enya K, Hayashi H, Takii T, Ohoka N, Kanata S, Okamoto T, Onozaki K.
  • Journal Title: J.Leuk.Biol. 83(1) Pages: 190-199
• [Journal Article] The interaction with Spl and reduction in the activity of histone deacetylase l are critical for the constitutive gene expression of IL-1α in human melanoma cells. (2008)
  • Author(s): K. Enya, H. Hayashi, T. Takii, N. Ohoka, S. Kanata, T. Okamoto, K. Onozaki
  • Journal Title: J. Leuk. Biol. 83(1) Pages: 190-199
  • Peer Reviewed
• [Journal Article] Contribution of extracellular signal-regulated kinases to the IL-1-induced growth inhibition of human melanoma cells A375. (2008)
  • Author(s): T. Arakawa, T. Yamamura, T. Hattori, H. Hayashi, A. Mori, A. Yoshida, C. Uchida, M. Kitagawa, K. Onozaki
  • Journal Title: Int Immunopharmacol. 8(1) Pages: 80-89
  • Peer Reviewed
• [Journal Article] Cigarette smoke condensate upregulates the gene and protein expressin of proinflammatory cytokines in humanfibroblast-like synoviocyte line. (2008)
  • Author(s): M. Shizu, 他12名の中の最後
  • Journal Title: J. Interferon Cytokine Res. 28(8) Pages: 509-521
  • Peer Reviewed
• [Journal Article] Inhibition of human immunodeficiency virus type l replication by blocking IkappaB kinase with noraristeromycin. (2008)
  • Author(s): K. Asamitsuk, 他7名中の6番目
  • Journal Title: J. Biochem. 144(5) Pages: 581-589
  • Peer Reviewed
• [Presentation] マウス関節炎の発症増強作用を示すタバコ成分に関する研究 (2011)
  • Author(s): 秋田邦彦, 岡本翔佑, 中条里美, 足達実季, 山田恭平, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
  • Organizer: 日本薬学会第131回年会 p253
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] タバコ抽出物によるマウス関節炎の増強作用 (2011)
  • Author(s): 足達実季, 岡本翔佑, 中條里美, 山田恭平, 秋田邦彦, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
  • Organizer: 日本薬学会第131回年会 p253
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] ジチオカルバメート誘導体の抗結核作用の機序についての検討 (2011)
  • Author(s): 堀田康弘, 瀧井猛将, 千葉拓, 藤原永年, 小川賢二, 黒石隆司, 稲垣衣美, 小野嵜菊夫
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] Mycobacterium bovis BCGの免疫持続に関する研究 (2011)
  • Author(s): 谷口恵一, 瀧井猛将, 林大介, 丸山光生, 小野嵜菊夫
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 2-acetamide-2-deoxy-β-D-glucopyranosylN,N-dimethyldithiocarbamate(OCT313)の抗結核作用についての検討 (2011)
  • Author(s): 長谷川倫宏, 瀧井猛将, 堀田康弘, 千葉拓, 黒石隆司, 小野嵜菊夫
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] 黄色ブドウ球菌分泌タンパク質SSL6はficolin-βに結合する (2011)
  • Author(s): 横山領介, 伊藤佐生智, 鴨志田剛, 瀧井猛将, 辻勉, 小野嵜菊夫
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] マウス関節炎の発症増強作用を示すタバコ成分に関する研究 (2011)
  • Author(s): 秋田邦彦, 他8名中9番目
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] タバコ抽出物によるマウス関節炎の増強作用 (2011)
  • Author(s): 足達実季, 他8名中9番目
  • Organizer: 日本薬学会 第131回年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-30
• [Presentation] Staphylococcal superantigen-like protein 6 (SSL6)はブタフィコリンβに結合する (2010)
  • Author(s): 横山領介, 伊藤佐生智, 鴨志田剛, 瀧井猛将, 辻勉, 小野嵜菊夫
  • Organizer: 第56回 日本薬学会東海支部総会・大会
  • Place of Presentation: 岐阜
  • Year and Date: 2010-07-03
• [Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta expression through NF-κB activation than OA patient-derived synoviocytes, human lung fibroblasts and human lung epithelial cells (2010)
  • Author(s): K.Onozaki, S.Okamoto, M.Yokoyama, T.Arakawa, M.Adachi, K.Yamada, K.Akita, S.Itoh, T.Takii, Y.Wagur i-Nagaya, T.Otsuka, K.Hayakawa
  • Organizer: 18th International Symposium on Molecular Cell Biology of Macrophages 2010
  • Place of Presentation: 熊本
  • Year and Date: 2010-05-20
• [Presentation] 男性ホルモンによる関節リウマチ滑膜細胞からの炎症性サイトカインの産生抑制 0P-pm035 (2010)
  • Author(s): 許鍵, 伊藤友香, 瀧井猛将, 林秀敏, 小野嵜菊夫
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta mRNA expression through NF-・B activation than OA patient-derived synoviocytes (2010)
  • Author(s): 小野嵜菊夫, 岡本翔佑, 伊藤佐生智, 瀧井猛将
  • Organizer: human lung fibroblasts and human lung epithelial cells 14th International Congress of Immunology 2010 PP-036-13
  • Place of Presentation: Kobe, Japan
• [Presentation] トリ型結核菌亜種のアンモニア産生におけるArginine deiminaseの関与 (2010)
  • Author(s): 山本龍二、瀧井猛将、堀田康弘、小川賢二、小野嵜菊夫
  • Organizer: 第9回 次世代を担う若手ファーマ・バイオフォーラム2010
  • Place of Presentation: 京都
• [Presentation] タバコと関節リウマチに関する研究 (2010)
  • Author(s): 足達実季, 岡本翔佑, 中條里美, 山田恭平, 秋田邦彦, 伊藤佐生智, 瀧井猛将, 早川和一, 小野嵜菊夫
  • Organizer: フォーラム2010 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京
• [Presentation] 黄色ブドウ球菌スーパー抗原様分泌タンパク質SSLファミリーによる補体活性化抑制作用 (2010)
  • Author(s): 伊藤佐生智, 濱田恵里, 鴨志田剛, 横山領介, 瀧井猛将, 小野嵜菊夫, 辻勉
  • Organizer: フォーラム2010 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京
• [Presentation] インターロイキン1によるヒトメラノーマ細胞増殖抑制機構の解析 (2010)
  • Author(s): 荒川友博, 林秀敏, 伊藤佐生智, 瀧井猛将, 小野嵜菊夫
  • Organizer: フォーラム2010 衛生薬学・環境トキシコロジー
  • Place of Presentation: 東京
• [Presentation] BCG亜株の抗原提示能の差異およびBCGワクチンの有効性に関する研究 (2010)
  • Author(s): 谷口恵一、瀧井猛将、林大介、矢野郁也、山本三郎、丸山光生、小野嵜菊夫
  • Organizer: 第22回微生物シンポジウム
  • Place of Presentation: 大阪
• [Presentation] 黄色ブドウ球菌スーパー抗原様タンパク質SSL10はヒトIgGのFc部に結合し古典経路による補体活性化を抑制する (2010)
  • Author(s): 伊藤佐生智, 他6名中6番目
  • Organizer: 第22回微生物シンポジウム
  • Place of Presentation: 大阪
• [Presentation] Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guerin (BCG) substrains (2010)
  • Author(s): D.Hayashi, 他14名中15番目
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: 神戸
• [Presentation] Staphylococcal superantigen-like protein 10 binds to human immunoglobulin G and inhibits the classical complement activation pathway (2010)
  • Author(s): S.Itoh, E.Hamada, G.Kamoshida, T.Takii, K.Onozaki, T.Tsuji
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: 神戸
• [Presentation] Rheumatoid arthritis patient-derived synoviocytes are more sensitive to cigarette smoke condensate extracts-induced IL-1 beta mRNA expression through NF-κB activation than OA patient-derived synoviocytes, human lung fibroblasts and human lung epithelial cells (2010)
  • Author(s): K.Onozaki, S.Okamoto, S.Itoh, T.Takii
  • Organizer: 14th International Congress of Immunology 2010
  • Place of Presentation: 神戸
• [Presentation] Staphylococcal superantigen-like protein 5(SSL5)inhibits matrix metalloproteinase(MMP)-9 and impairs trafficking of neutrophils (2009)
  • Author(s): 伊藤佐生智, 横山領介, 辻勉, 瀧井猛将, 小野崎菊夫
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Cigarette smoking and rheumatoid arthritis : Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice (2009)
  • Author(s): 岡本翔佑, 林秀敏, 瀧井猛将, 小野嵜菊夫
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-12-04
• [Presentation] Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology (2009)
  • Author(s): Onozaki K, Chujo S, Okamoto S, Sunahara R, Itoh Y, Hayashi H, Takii T, Hayakawa K
  • Organizer: International Cytokine Society, & International Society for Interferon and Cytokine Research
  • Place of Presentation: Lisbon
  • Year and Date: 2009-11-21
• [Presentation] Cigarette smoke condensate extracts induce proinflammatory cytokines from synovial cells and exacerbate collagen-induced arthritis in mice (2009)
  • Author(s): 小野嵜菊夫, 他7名
  • Organizer: Tri-Society Annual Conference 2009 of the Society for Leukocyte Biology, International Cytokine Society, & International Society for Interferon and Cytokine Research
  • Place of Presentation: Lisbon,(ポルトガル)
  • Year and Date: 2009-11-21
• [Presentation] 多剤耐性結核菌に有効な新規糖化合物の探索 (2009)
  • Author(s): 堀田康弘, 瀧井猛将, 千葉拓, 黒石隆司, 小野嵜菊夫
  • Organizer: 第8回 次世代を担う若手ファーマ・バイオフォーラム2009
  • Place of Presentation: 名古屋
  • Year and Date: 2009-11-14
• [Presentation] タバコと関節リウマチに関する研究 (2009)
  • Author(s): 岡本翔佑, 中条里美, 瀧井猛将, 林秀敏, 早川和一, 小野嵜菊夫
  • Organizer: フォーラム2009:衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] G2/M期でのストレス誘導性 pseudokinase TRB3の役割 (2009)
  • Author(s): 酒井聡, 大岡伸通, 小野嵜菊夫, 中西真, 林秀敏
  • Organizer: フォーラム2009:衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] 滑膜細胞における浸透圧センサーTRPV4のケモカイン産生に及ぼす影響 (2009)
  • Author(s): 伊藤友香, 波多野紀行, 林秀敏, 小野嵜菊夫, 村木克彦
  • Organizer: フォーラム2009:衛生薬学・環境トキシコロジー
  • Place of Presentation: 沖縄
  • Year and Date: 2009-11-05
• [Presentation] ユビキチンリガーゼAPC/C Cdh1による pseudokinase TRB3の発現制御機構の解明 (2009)
  • Author(s): 酒井聡, 大岡伸通, 北川雅敏, 中西真, 小野嵜菊夫, 林秀敏
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] 小胞体ストレス誘導性細胞死における pseudokinase TRB3の役割 (2009)
  • Author(s): 中田佳宏, 酒井聡, 大岡伸通, 小野嵜菊夫, 林秀敏
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Comparable Sstudy between Conventional Biochemical Tests and Susceptibility to Environmental Stresses among/Mycobacterium bovis/BCG sub-strains (2009)
  • Author(s): 瀧井猛将, 他8名中9番目13名中14番目
  • Organizer: Keystone symposia Overcoming the crisis of TB and AIDS
  • Place of Presentation: Arusha, Tanzania
  • Year and Date: 2009-10-23
• [Presentation] Synthesis and Biological Evaluation of a New sugar Derivative as Antibacterial Agents for Mycobacterium tuberculosis (2009)
  • Author(s): 堀田康弘, 他8名中9番目
  • Organizer: Keystone symposia Overcoming the crisis of TB and AIDS
  • Place of Presentation: Arusha, Tanzania
  • Year and Date: 2009-10-21
• [Presentation] トリ型結核菌亜種の酸耐性メカニズムの差異に関する研究 (2009)
  • Author(s): 山本龍二, 堀田康弘, 小川賢二, 小野嵜菊夫, 瀧井猛将
  • Organizer: 第21回微生物シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2009-09-04
• [Presentation] 黄色ブドウ球菌スーパー抗原様タンパク質SSL5による好中球マトリックスメタロプロテイナーゼの阻害 (2009)
  • Author(s): 伊藤佐生智, 他8名中の7番目
  • Organizer: 第21回微生物シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2009-09-04
• [Presentation] BCG亜株の生化学的性状と宿主内生存能力の比較検討 (2009)
  • Author(s): 安田恵実, 他7人中の8番目
  • Organizer: 第21回微生物シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 2009-09-04
• [Presentation] Staphylococcal superantigen-like protein 5(SSL5)inhibits matrix metalloproteinase-9 from human neutrophils (2009)
  • Author(s): 伊藤友香, 他8名中の8番目
  • Organizer: 17th International Symposium on Mocelular Cell Biology of Macrophages
  • Place of Presentation: 金沢
  • Year and Date: 2009-07-03
• [Presentation] Cigarette smoke condensate extracts induce proinflammatory cytokines by synovial cells and exacerbate collagen-induced arthritis in mice (2009)
  • Author(s): 中条里美, 他7名中の8番目
  • Organizer: 17th International Symposium on Mocelular Cell Biology of Macrophages
  • Place of Presentation: 金沢
  • Year and Date: 2009-07-03
• [Presentation] Mycobacterium bovis BCG亜株間の自然免疫誘導活性の差異とミコール酸の関与 (2009)
  • Author(s): 安田恵実, 林大介, 瀧井猛将, 藤原永年, 山本三郎, 矢野郁也, 小野寄菊夫
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-13
• [Presentation] Mycobacterium bovis BCG亜株の生化学的性状と宿主細胞内生存能の差異 (2009)
  • Author(s): 林大介, 安田恵実, 瀧井猛将, 矢野郁也, 山本三郎, 小野嵜菊夫
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-13
• [Presentation] 老齢マウスにおける結核症に対するBCG免疫能に関する研究 (2009)
  • Author(s): 伊藤司, 林大介, 瀧井猛将, 丸山光生, 小野嵜菊夫
  • Organizer: 第82回日本細菌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-03-13
• [Presentation] インターロイキン1によるヒトメラノーマ細胞増殖抑制機構へのERK1/2経路の関与 (2008)
  • Author(s): 荒川友博, 林 秀敏, 瀧井猛将, 小野嵜菊夫
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-12
• [Presentation] G2/M移行期におけるpseudokinase TRB3の役割 (2008)
  • Author(s): 酒井 聡, 大岡伸通, 丹伊田浩行, 小野寄菊夫, 中西 真, 林 秀敏
  • Organizer: 第31回日本分子生物学会年会第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-10
• [Presentation] インターロイキン1によるヒトメラノーマ細胞増殖抑制機構へのERK1/2経路の関与 (2008)
  • Author(s): 荒川友博, 林 秀敏, 瀧井猛将, 小野嵜菊夫
  • Organizer: 平成20年度日本薬学会東海支部例会
  • Place of Presentation: 静岡
  • Year and Date: 2008-12-06
• [Presentation] ポリオウイルスベクターを用いた新規結核ワクチンの開発 (2008)
  • Author(s): D. Hayashi, T. Takii, T. Ito, M. Okada, K. Onozaki
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-02
• [Presentation] ストレス誘導性pseudokinase TRB3のT細胞分化に及ぼす影響 (2008)
  • Author(s): H. Hayashi, K. Onozaki
  • Organizer: 第38回日本免疫学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] 新規ストレス誘導性分子TRB3によるT細胞分化制御 (2008)
  • Author(s): 西仲 駿, 森田陽子, 酒井 聡, 小野寄菊夫, 林 秀敏
  • Organizer: フォーラム2008 : 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-18
• [Presentation] タバコと関節リウマチに関する研究 (2008)
  • Author(s): 中條里美, 岡本翔佑, 砂原良平伊藤友香, 瀧井猛将, 林秀敏, 早川和一, 小野寄菊夫
  • Organizer: フォーラム2008 : 衛生薬学・環境トキシコロジー
  • Place of Presentation: 熊本
  • Year and Date: 2008-10-18
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/esk/index.html