| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Mutations in oncogene and tumor suppressor gene lead to malignant transformation. Dysregulation of DNA methylation and histone modification is also found in cancer. Epigenetic studies are also required to understand molecular mechanisms of carcinogenesis and tumorigenesis. Here, we revealed that epigenetics regulatory factors, which induced hepatocarcinogenesis, including histone acetyltransferase, histone methyltransferase, and histone variant, regulated gene expression of tumor marker, cell proliferation, and anchorage-independent growth.
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