Analysis of the functional interactions of factors concerned with histones in malignant transformation.
| Project/Area Number |
20590065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
OSADA Shigehiro Nagoya City University, 大学院・薬学研究科, 准教授 (40263305)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エピジェネティクス / ヒストン / クロマチン / アセチル化 / メチル化 / 発がん / 細胞がん化 / 腫瘍マーカー / 脱アセチル化 / ヒストンバリアント |
|---|
| Research Abstract |
Mutations in oncogene and tumor suppressor gene lead to malignant transformation. Dysregulation of DNA methylation and histone modification is also found in cancer. Epigenetic studies are also required to understand molecular mechanisms of carcinogenesis and tumorigenesis. Here, we revealed that epigenetics regulatory factors, which induced hepatocarcinogenesis, including histone acetyltransferase, histone methyltransferase, and histone variant, regulated gene expression of tumor marker, cell proliferation, and anchorage-independent growth.
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Report
(4 results)
Research Products
(22 results)
