| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is one of the most important antioxidant enzymes that directly reduce phospholipid hydroperoxide generated in biomembrane by oxidative stress. Disruption of GPx4 induce cell death in in several tissues and MEF cells. Several experiments demonstrated that this cell death induced by depletion of GPx4 is not a canonical cell death, such as apoptosis, necrosis and autophagic cell death, but a novel cell death.
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