セレン蛋白質GPx4による新規細胞増殖制御機構の解析
Project/Area Number |
20590067
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Kitasato University |
Principal Investigator |
IMAI Hirotaka Kitasato University, 薬学部, 准教授 (50255361)
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Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | グルタチオンペルオキシダーゼ / 細胞死 / リピドミクス / 化合物ライブラリー / ビタミンE / 脂質酸化 / 非アポトーシス / セレン蛋白質 / GPx / スフィンゴミエリン / shRNA / スフィンゴミエリン合成酵素 / GPx2 / アポトーシス / ネクローシス / オートファジー / 脂質過酸化 / 細胞増殖 |
Research Abstract |
Phospholipid hydroperoxide glutathione peroxidase (GPx4) is one of the most important antioxidant enzymes that directly reduce phospholipid hydroperoxide generated in biomembrane by oxidative stress. Disruption of GPx4 induce cell death in in several tissues and MEF cells. Several experiments demonstrated that this cell death induced by depletion of GPx4 is not a canonical cell death, such as apoptosis, necrosis and autophagic cell death, but a novel cell death.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article]2009
Author(s)
Imai H., Hakkaku N., Iwamoto R., Suzuki J., Suzuki T., Tajima Y., Konishi K., Minami S., Ichinose S., Ishizaka K., Shioda S., Arata S., Nishimura M., Naito S., Nakagawa Y.
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Journal Title
J.Biol.Chem. 284
Pages: 32522-32532
Related Report
Peer Reviewed
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