Molecular target study for Kaposi sarcoma-associated virus-associated diseases
| Project/Area Number |
20590068
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Keio University |
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Principal Investigator |
NOGUCHI Kohji Keio University, 薬学部, 准教授 (80291136)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がんウイルス / 分子標的 / 遺伝子 / 抗ウイルス薬 / KSHV / ヘルペスウイルス / がん / 抗がん剤 / 感受性 / NF-kappaB / cyclin / NF-KappaB |
|---|
| Research Abstract |
In this study, we examined the effects of KSHV-associated viral gene expressions on cellular chemosensitivity to various drugs. Our results showed that vFLIP expression apparently conferred bleomycin sensitivity in HEK293 cells. Moreover, knockdown experiment for Ikappa-Balpha showed similar results, suggesting that an activation of NF-kappaB pathway contributes to the belomycin chemosensitization induced by vFLIP.
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Report
(4 results)
Research Products
(48 results)
