• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular target study for Kaposi sarcoma-associated virus-associated diseases

Research Project

Project/Area Number 20590068
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionKeio University

Principal Investigator

NOGUCHI Kohji  Keio University, 薬学部, 准教授 (80291136)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsがんウイルス / 分子標的 / 遺伝子 / 抗ウイルス薬 / KSHV / ヘルペスウイルス / がん / 抗がん剤 / 感受性 / NF-kappaB / cyclin / NF-KappaB
Research Abstract

In this study, we examined the effects of KSHV-associated viral gene expressions on cellular chemosensitivity to various drugs. Our results showed that vFLIP expression apparently conferred bleomycin sensitivity in HEK293 cells. Moreover, knockdown experiment for Ikappa-Balpha showed similar results, suggesting that an activation of NF-kappaB pathway contributes to the belomycin chemosensitization induced by vFLIP.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (48 results)

All 2011 2010 2009 2008

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (32 results)

  • [Journal Article] Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.2010

    • Author(s)
      Yoshioka H, Noguchi K, et al.
    • Journal Title

      Biochem Biophys Res Commun. 394

      Pages: 1000-1005

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene.2010

    • Author(s)
      Kawahara H, Noguchi K, Sugimoto Y, et al.
    • Journal Title

      Cancer Sci. 101

      Pages: 1493-1500

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate.2010

    • Author(s)
      Mitsuhashi J, Noguchi K, Sugimoto Y, et al.
    • Journal Title

      J Gene Med. 12

      Pages: 596-603

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization. Cancer Sci.2010

    • Author(s)
      Shigeta J, Noguchi K, Sugimoto Y, et al.
    • Journal Title

      101 1813-1821

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional availability of gamma-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a.2010

    • Author(s)
      Yoshioka H
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 394 Pages: 1000-1005

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological interaction with sunitinib is abolished by a germ-line mutation (1291T>C) of BCRP/ABCG2 gene.2010

    • Author(s)
      Kawahara H
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 1493-1500

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BCRP/ABCG2 confers anticancer drug resistance without covalent dimerization.2010

    • Author(s)
      Shigeta J
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 1813-1821

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo expansion of MDR1-transduced cells accompanied by a post-transplantation chemotherapy regimen with mitomycin C and methotrexate.2010

    • Author(s)
      Mitsuhashi J
    • Journal Title

      Journal of Gene Medicine

      Volume: 12 Pages: 596-603

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological Interplay between breast cancer resistance protein and gefitinib in epidermal growth factor receptor signaling.2009

    • Author(s)
      Katayama K, Noguchi K, Sugimoto Y, et al.
    • Journal Title

      Anticancer Res 29

      Pages: 1059-1065

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib.2009

    • Author(s)
      Noguchi K, Sugimoto Y, et al.
    • Journal Title

      Cancer Sci. 100

      Pages: 1701-1707

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR.2009

    • Author(s)
      Murakami Y, Noguchi K, et al.
    • Journal Title

      Antiviral Res 83

      Pages: 112-117

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functions of the breast cancer resistance protein (BCRP/ABCG2) in chemotherapy.2009

    • Author(s)
      Noguchi K, Sugimoto Y, et al.
    • Journal Title

      Adv Drug Deliv Rev. 61

      Pages: 26-33

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of bisindolylmaleimides and indolocarbazoles as inhibitors of HCV replication by tube-capture-RT-PCR2009

    • Author(s)
      Murakami Y
    • Journal Title

      Antiviral Research 83

      Pages: 112-117

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Substrate-dependent bidirectional modulation of P-glycoprotein-mediated drug resistance by erlotinib2009

    • Author(s)
      Noguchi K
    • Journal Title

      Cancer Science 100

      Pages: 1701-1707

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pharmacological Interplay between breast cancer resistance protein and gefitinib in epidermal growth factor receptor signaling.2009

    • Author(s)
      Katayama K, 他
    • Journal Title

      Anticancer Research 29(掲載決定)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functions of the breast cancer resistance protein (BCRP/ABCG2)in chemotherapy2009

    • Author(s)
      Noguchi K, 他
    • Journal Title

      Advanced Drug Delivery Reviews 61

      Pages: 26-33

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] EBNA1機能阻害剤による抗EBV作用2011

    • Author(s)
      野口耕司
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] EBNA1蛋白質のDNA結合能を阻害する化合物の探索研究2010

    • Author(s)
      野口耕司
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトiPS細胞におけるレトロウイルス挿入部位の同定と評価2010

    • Author(s)
      山原裕輔
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Epstein-Barr virus由来のEBNA1蛋白質に対する機能阻害剤の探索2010

    • Author(s)
      安田愛
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] プロテアソーム阻害剤UO126によるP-糖タンパク質の発現低下を克服する2010

    • Author(s)
      片山和浩
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Functional availability of KSHV cyclin is regulated by cellular CDK6 and p16INK4a.2010

    • Author(s)
      Noguchi K, Yoshioka H, Maeda A, Katayama K, Mitsuhashi J, Sugimoto Y.
    • Organizer
      13th International Workshop on Kaposi's Sarcoma Associated Herpesvirus (KSHV) and Related Agents.
    • Place of Presentation
      Los Angeles, CA, USA
    • Year and Date
      2010-08-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Functional availability of KSHV cyclin is regulated by cellular CDK6 and p16INK4a.2010

    • Author(s)
      野口耕司
    • Organizer
      13th International Workshop on Kaposi's Sarcoma Associated Herpesvirus (KSHV) and Related Agents
    • Place of Presentation
      Los Angeles, CA, USA
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] がんウイルスEpstein-Barr Virus由来のEBNA1蛋白質のDNA結合能を阻害する化合物の探索研究2010

    • Author(s)
      野口耕司,片山和浩,蓑島維文,板東俊和,杉山弘,杉本芳一
    • Organizer
      第14回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-07
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Kaposi's sarcoma-associated herpesvirus (KSHV)由来k-cyclinの制御機構2010

    • Author(s)
      吉岡秀哲、片山和浩、三橋純子、杉本芳一,野口耕司
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] Kaposi's sarcoma-associated herpesvirus(KSHV)由来k-cyclinの制御機構2010

    • Author(s)
      吉岡秀哲
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] がんウイルスEpstein-Barr Virus由来のEBNA1を新規分子標的とする阻害薬の探索研究2010

    • Author(s)
      安田愛,片山和浩,三橋純子,蓑島維文,板東俊和,杉山弘,山越智,杉本芳一,野口耕司
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ヒトiPS細胞におけるレトロウイルス挿入部位の同定と評価(1)2010

    • Author(s)
      岩崎佳奈
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトiPS細胞におけるレトロウイルス挿入部位の同定と評価(2)2010

    • Author(s)
      山原裕輔
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] MAPK経路によるP-糖タンパク質の発現制御2010

    • Author(s)
      笹波瑛子
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] U0126によるP-糖タンパク質の発現制御機構の解明2010

    • Author(s)
      片山和浩
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ヒトABCB5の機能解析2010

    • Author(s)
      佐藤麻恵
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] がんウイルス Epstein-Barr Virus 由来のEBNA1を新規分子標的とする阻害薬の探索研究2010

    • Author(s)
      安田愛
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Chemosensitization to bleomycin conferred by a constitutive activation of IKK pathway in viral FLIP expressing cells.2009

    • Author(s)
      Kohji Noguchi, Yuri Masuda, Kazuhiro Katayama, Junko Mitsuhashi, Yoshikazu Sugimoto
    • Organizer
      AACR-EORTC-NCI Molecular Targets and Cancer Therapeutics Conference 2009
    • Place of Presentation
      Boston, MA, USA
    • Year and Date
      2009-11-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Chemosensitization to bleomycin conferred by a constitutive activation of IKK pathway in viral FLIP expressing cells2009

    • Author(s)
      野口耕司
    • Organizer
      2009 AACR-EORTC-NCI Molecular Targets and Cancer Therapeutics Conference
    • Place of Presentation
      米国マサチューセッツ州ボストン
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] ABCトランスポーターのP-gp/ABCB1、BCRP/ABCG2に対するsunitinibの効果の違い2009

    • Author(s)
      河原はる香,野口耕司,片山和浩,三橋純子,杉本芳一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] カポジ肉腫関連ウイルス由来vFLIPの発現とブレオマイシン感受性2009

    • Author(s)
      野口耕司,増田由梨,片山和浩,杉本芳一
    • Organizer
      第57 回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] カポジ肉腫関連ウイルス由来vFLIPの発現とブレオマイシン感受性2009

    • Author(s)
      野口耕司
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] カポジ肉腫関連ヘルペスウイルス由来vFLIP発現細胞のBleomycin高感受性について2009

    • Author(s)
      増田由梨、野口耕司、三橋純子、片山和浩、杉本芳一
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2010 Final Research Report
  • [Presentation] カポジ肉腫関連ヘルペスウイルス由来vFLIP発現細胞の Bleomycin 高感受性について2009

    • Author(s)
      増田由梨
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] ABCトランスポーターのP-gp/ABCB1、BCRP/ABCG2に対する sunitinib の効果の違い2009

    • Author(s)
      河原はる香
    • Organizer
      第68回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2009-10-01
    • Related Report
      2009 Annual Research Report
  • [Presentation] Retrovirus integration site analysis if human induced pluripotent stem(iPS)cells2009

    • Author(s)
      杉本芳一
    • Organizer
      第15回日本遺伝子治療学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] カポジ肉腫関連ウイルス由来vFLIP発現と抗がん剤感受性2009

    • Author(s)
      野口耕司、片山和浩、杉本芳一
    • Organizer
      第13回日本がん分子標的治療学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2009-06-26
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] KSHV/HHV-8 viral genes expression modulates chemosensitivity of human 293 cells2008

    • Author(s)
      野口耕司,片山和浩,杉本芳一
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-28
    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Presentation] カポシ肉腫関連ウイルスの遺伝子発現と抗がん剤感受性変化2008

    • Author(s)
      野口耕司,片山和浩,杉本芳一
    • Organizer
      第56 回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] カポシ肉腫関連ウイルスの遺伝子発現と抗がん剤感受性変化2008

    • Author(s)
      野口耕司, 他
    • Organizer
      第56回日本ウイルス学会学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2008-10-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] がん関連ウイルスの遺伝子発現による抗がん剤感受性への影響2008

    • Author(s)
      吉岡秀哲,片山和浩,野口耕司,杉本芳一
    • Organizer
      第52 回日本薬学会関東支部大会
    • Place of Presentation
      野田
    • Year and Date
      2008-10-04
    • Related Report
      2010 Final Research Report
  • [Presentation] カポシ肉腫関連ウイルスの分子標的に関する研究2008

    • Author(s)
      野口耕司,片山和浩,杉本芳一
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2010 Final Research Report 2008 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi