Research for host-recognition and responses against endotoxin modified by pathogenic bacteria.
| Project/Area Number |
20590073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Doshisha Women's College of Liberal Arts |
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Principal Investigator |
KAWASAKI Kiyoshi Doshisha Women's College of Liberal Arts, 薬学部, 教授 (60270641)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | エンドトキシン / Toll-like receptor / 細菌 / 外膜 / 潜伏化 / 脱アシル化 / リポ多糖 / 活性調節 / 膜透過性 / 脂質 / シグナル伝達 / 自然免疫 |
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| Research Abstract |
Regulatory machineries of lipid A modification enzymes were analyzed in this study. Lipid A modification enzyme PagL is usually latent, and the property of PagL to associate with lipopolysaccharide was shown to be important for the latency. Furthermore, the biological significance of the PagL latency was examined. PagL latency was shown to be beneficial for bacteria to produce effective membrane permeation barrier.
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Report
(5 results)
Research Products
(26 results)
