Characterization and physiological significance of the interaction between mannan-binding protein and matrix metalloproteases.

• Project/Area Number: 20590074
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Ritsumeikan University
• Principal Investigator: KAWASAKI Nobuko Ritsumeikan University, 総合理工学研究機構, 教授 (70077676)
• Co-Investigator(Kenkyū-buntansha): KAWASAKI Toshisuke 立命館大学, 総合理工学研究機構, 教授 (50025706)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: マンナン結合タンパク質 / マンナン結合レクチン / メプリン / マトリックスメタロプロテアーゼ / レクチン / 糖鎖 / 補体活性化 / 腎虚血再灌流 / マンノース結合レクチン / 酵素 / 糖タンパク質

Research Abstract

The molecular mechanism of the interaction between a Ca^<2+>-dependent lectin, mannanbinding protein (MBP) and metalloproteases, meprins and its functional roles in the ischemia/reperfusion-operated mouse kidneys were studied.

Research Products

• [Journal Article] Dendritic cellspecific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas (2011)
  • Author(s): M.Nonaka, BY.Ma, H.Imaeda, K.Yamaguchi, N.Kawasaki, K.Hodohara, N.Kawasaki, A.Andoh, Y.Fujiyama, T.Kawasaki
  • Journal Title: Journal of Biological Chemistry(First Published Online on April 22, 2011) (in press)
  • Peer Reviewed
• [Journal Article] Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas. (2011)
  • Author(s): Motohiro Nonaka
  • Journal Title: Journal of Biological Chemistry Volume: (印刷中(掲載確定))
  • Peer Reviewed
• [Journal Article] Recognition of Endogenous Ligands by C-Type Lectins : Interaction of Serum Mannan-binding Protein with Tumorassociated Oligosaccharide Epitopes. (2010)
  • Author(s): N.Kawasaki, T.Kawasaki
  • Journal Title: Trends in Glycoscience and Glycotechnology 22 Pages: 141-151
  • NAID: 10027508427
  • Peer Reviewed
• [Journal Article] Recognition of Endogenous Ligands by C-Type Lectins : Interaction of Serum Mannan-binding Protein with Tumor-associated Oligosaccharide Epitopes (2010)
  • Author(s): Nobuko Kawasaki
  • Journal Title: TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY Volume: 22 Pages: 141-151
  • NAID: 10027508427
  • Peer Reviewed
• [Journal Article] Characterization of the Interaction of between Serum Mannan-binding Protein and Nucleic acid Ligands. (2009)
  • Author(s): N.Nakamura, M.Nonaka, BY.Ma, S.Matsumoto, N.Kawasaki, S.Asano, T.Kawasaki
  • Journal Title: Journal of Leucocyte Biology 86 Pages: 737-748
  • Peer Reviewed
• [Journal Article] Highly Fucosylated N-Glycan Ligands for Mannan-binding Protein Expressed Specifically on CD26 (DPPVI) Isolated from a Human Colorectal Carcinoma Cell Line, SW1116. (2009)
  • Author(s): N.Kawasaki, C-W.Lin, R.Inoue, K-H.Koo, N.Kawasaki, B-Y.Ma, S.Oka, M.Ishiguro, T.Sawada, H.Ishida, T.Hashimoto, T.Kawasaki
  • Journal Title: Glycobiology 19 Pages: 437-450
  • Peer Reviewed
• [Journal Article] The Lectin Jacalin Induces Human B Lymphocyte Apoptosis through Glycosylationdependent Interaction with CD45. (2009)
  • Author(s): BY.Ma, K.Yoshida, M.Baba, M.Nonaka, S.Matsumoto, N.Kawasaki, S.Asano, T.Kawasaki
  • Journal Title: Immunology 127 Pages: 477-488
  • Peer Reviewed
• [Journal Article] Highly fucosylated N-glycan ligands for mannan-binding protein expressed specifically on CD26(DPPVI)isolated from a human colorectal carcinoma cell line, SW1116. (2009)
  • Author(s): Nobuko Kawasaki
  • Journal Title: Glycobiology 19 Pages: 437-450
  • Peer Reviewed
• [Journal Article] The lectin Jacalin induces human B lymphocyte apoptosis through glycosylation-dependent interaction with CD45. (2009)
  • Author(s): Bruce Yong Ma
  • Journal Title: Immunology 127 Pages: 477-488
  • Peer Reviewed
• [Journal Article] Characterization of the interaction between serum mannan-binding protein and nucleic acid ligands. (2009)
  • Author(s): Natsuko Nakamura
  • Journal Title: Journal of Leukocyte Biology 86 Pages: 737-748
  • Peer Reviewed
• [Journal Article] Highly fucosylated N-glycan ligands for mannan-binding protein expressed specifically on CD26 (DPPVI) isolated from a human colorectal carcinoma cell line, SW1116 (2009)
  • Author(s): Nobuko Kawasaki
  • Journal Title: Glycobiology 19 Pages: 437-450
  • Peer Reviewed
• [Presentation] C-Type lectin DC-SIGN interacts with Mac-2BP expressed on human colon tumors. (2010)
  • Author(s): 野中元裕,Ma BY.、山口圭子,川嵜伸子,川嵜敏祐
  • Organizer: BMB2010(第33回日本分子生物学会年会・第83回日本生化学大会合同大会)
  • Place of Presentation: 神戸ポートアイランド、神戸市(兵庫県)
  • Year and Date: 2010-12-10
• [Presentation] C-Type lectin DC-SIGN interacts with Mac-2BP expressed on human colon tumors (2010)
  • Author(s): 野中元裕
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド(兵庫)
  • Year and Date: 2010-12-10
• [Presentation] Mac-2 BP Expressed on Human Colon Carcinomas is a Novel Ligand for DC-Sign. (2010)
  • Author(s): M.Nonaka, BY.Ma, N.Kawasaki,T.Kawasaki
  • Organizer: Annual Conference of the Society for Glycobiology(2010)
  • Place of Presentation: St.Pete Beach(Florida, USA)
  • Year and Date: 2010-11-10
• [Presentation] Mac-2 BP Expressed on Human Colon Carcinomas is a Novel Ligand for DC-Sign (2010)
  • Author(s): Motohiro Nonaka
  • Organizer: Annual Conference of the Society for Glycobiology 2010
  • Place of Presentation: St.Pete Beach, Florida, USA
  • Year and Date: 2010-11-10
• [Presentation] Recognition of Tumor-associated Oligosaccharides by Serum Mannan-binding Protein. (2010)
  • Author(s): T.Kawasaki, N.Kawasaki, M.Nonaka, BY.Ma
  • Organizer: Annual Conference of the Society for Glycobiology, 2010
  • Place of Presentation: St.Pete Beach(Florida, USA)
  • Year and Date: 2010-11-07
• [Presentation] Recognition of Tumor-associated Oligosaccharides by Serum Mannan-binding Protein (2010)
  • Author(s): Toshisuke Kawasaki
  • Organizer: Annual Conference of the Society for Glycobiology 2010
  • Place of Presentation: St.Pete Beach, Florida, USA
  • Year and Date: 2010-11-07
• [Presentation] C-Type Lectin DC-SIGN Recognizes Glycans of Mac-2BP Expressed on Colorectal Cancer. (2010)
  • Author(s): M.Nonaka,BY. Ma, S.Matsumoto, K.Yamaguchi, N.Kawasaki, N.Kawasaki, T.Kawasaki
  • Organizer: 25th International Carbohydrate Symposium
  • Place of Presentation: 幕張メッセ国際会議場、千葉市(千葉県)
  • Year and Date: 2010-08-02
• [Presentation] C-Type Lectin DC-SIGN Recognizes Glycans of Mac-2BP Expressed on Colorectal Cancer (2010)
  • Author(s): Motohiro Nonaka
  • Organizer: 25th International Carbohydrate Symposium
  • Place of Presentation: 幕張メッセ国際会議場(千葉)
  • Year and Date: 2010-08-02
• [Presentation] Interaction of Serum Mannan-binding Protein with Tumorassociated Oligosaccharide. (2010)
  • Author(s): T.Kawasaki, N.Kawasaki, M.Nonaka, BY.Ma, H.Imaeda, Y.Fujiyama, A.Andoh
  • Organizer: 7th International Symposium on Glycosyltransferases
  • Place of Presentation: 国際ファッションセンター、東京都
  • Year and Date: 2010-07-31
• [Presentation] Interaction of Serum Mannan-binding Protein with Tumor-associated Oligosaccharide. (2010)
  • Author(s): Toshisuke Kawasaki
  • Organizer: 7th International Symposium on Glycosyltransferases
  • Place of Presentation: 国際ファッションセンター、(東京都)
  • Year and Date: 2010-07-31
• [Presentation] CD26/DPPIVの糖鎖構造と酵素活性に関する研究 (2009)
  • Author(s): 山口圭子,大坪和明,荒川健司,Khoo K-H,川崎ナナ,中尾広美,野中元裕, Ma BY.,川嵜伸子,川嵜敏祐
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸ポートアイランド、神戸市(兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] 血清型マンナン結合タンパク質と核酸の相互作用とその生物学的意義 (2009)
  • Author(s): 野中元裕, Ma BY.,松本尚吾,川嵜伸子,川嵜敏祐
  • Organizer: 第82回日本生化学大会
  • Place of Presentation: 神戸ポートアイランド、神戸市(兵庫県)
  • Year and Date: 2009-10-24
• [Presentation] ルイスAモノマーおよびオリゴマー糖鎖を用いた抗ルイス糖鎖抗体の反応特異性解析 (2009)
  • Author(s): 山口圭子,中尾広美,長尾和弥,石田秀治,木曽真,福井成行,野中元裕,Ma BY.,川嵜伸子,川嵜敏祐
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 飛騨・世界生活文化センター、高山市(岐阜県)
  • Year and Date: 2009-09-11
• [Presentation] 血清型マンナン結合タンパク質による核酸の認識とその意義 (2009)
  • Author(s): 野中元裕,Ma BY.,中村奈都子,松本尚吾,川嵜伸子,川嵜敏祐
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 飛騨・世界生活文化センター、高山市(岐阜県)
  • Year and Date: 2009-09-11
• [Presentation] Interaction of mannan-binding protein and its high affinity ligands expressed on CD26 (DPPIV) isolated from a human colorectal carcinoma, SW1116. (2009)
  • Author(s): T.Kawasaki, N.Kawasaki, K-H.Khoo, K.Yamaguchi, M.Nonaka, BY.Ma
  • Organizer: 15th European carbohydrate symposium
  • Place of Presentation: Vienna (Austria)
  • Year and Date: 2009-07-21
• [Presentation] 虚血性腎障害におけるマンナン結合タンパク質とmeprinとの相互作用 (2009)
  • Author(s): 平野真、Ma BY.,川崎ナナ,川嵜伸子,川嵜敏祐
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館、京都市(京都府)
  • Year and Date: 2009-03-26
• [Presentation] Interaction of mannan-binding protein and its high affinity ligands expressed on CD26(DPPIV)isolated from a human colorectal carcinoma, SW1116. (2009)
  • Author(s): Toshisuke Kawasaki
  • Organizer: 15th European carbohydrate symposium
  • Place of Presentation: Vienna, Austria
• [Presentation] ルイスAモノマーおよびオリゴマー糖鎖を用いた抗ルイス糖鎖抗体の反応特異性解析. (2009)
  • Author(s): 山口圭子
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 飛騨・世界生活文化センター(岐阜県高山市)
• [Presentation] 血清型マンナン結合タンパク質による核酸の認識とその意義. (2009)
  • Author(s): 野中元裕
  • Organizer: 第29回日本糖質学会年会
  • Place of Presentation: 飛騨・世界生活文化センター(岐阜県高山市)
• [Presentation] CD26/DPPIVの糖鎖構造と酵素活性に関する研究. (2009)
  • Author(s): 山口圭子
  • Organizer: 第82回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド(兵庫県神戸市)
• [Presentation] 虚血性腎障害におけるマンナン結合タンパク質とmeprinとの相互作用 (2009)
  • Author(s): 平野真
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 国立京都国際会館, 京都市
• [Presentation] マンナン結合タンパク質に対して高親和性結合を示すリガンド糖鎖の構造的特徴 (2008)
  • Author(s): 山口圭子,川嵜伸子、Khoo,KH.,石黒正路,澤田敏彦,川崎ナナ,中尾広美,Ma BY.,川嵜敏祐
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学大会合同大会)
  • Place of Presentation: 神戸ポートアイランド、神戸市(兵庫県)
  • Year and Date: 2008-12-12
• [Presentation] 樹状細胞C型レクチンDC-SIGNによる結腸がん細胞表面糖鎖の認識と腫瘍免疫の調節機構 (2008)
  • Author(s): 野中元裕,Ma BY.,川嵜伸子,川嵜敏祐
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学大会合同大会)
  • Place of Presentation: 神戸ポートアイランド、神戸市(兵庫県)
  • Year and Date: 2008-12-12
• [Presentation] SPECIFIC INTERACTION OF MANNAN-BINDING PROTEIN WITH HIGHLY FUCOSYLATED POLY LACTOSAMINE-TYPE N-GLYCANS ISOLATED FROM HUMAN COLORECTAL CARCINOMA. (2008)
  • Author(s): N.Kawasaki, K-H. KHOO, R.INOUE, BY. Ma, T.Kawasaki
  • Organizer: The 23rd International Lectin Conference
  • Place of Presentation: University of Edinburgh, Edingburgh (Scotland)
  • Year and Date: 2008-07-12
• [Presentation] MOLECULAR MECHANISM OF THE INHIBITION OF PROTEOLYTIC ACTIVITY OF MEPRINS BY MBP. (2008)
  • Author(s): M.Hirano, N.Kawasaki, BY.Ma, T.Kawasaki
  • Organizer: The 23rd International Lectin Conference
  • Place of Presentation: University of Stirling, Nr Bridge of Allan (Scotland)
• [Presentation] MOLECULAR MECHANISM OF THE INHIBITION OF PROTEOLYTIC ACTIVITY OF MEPRINS BY MBP (2008)
  • Author(s): Nobuko Kawasaki
  • Organizer: The 23rd International Lectin Conference
  • Place of Presentation: Edinburgh & Stirling, Scotland
• [Presentation] マンナン結合タンパク質に対して高親和性結合を示すリガンド糖鎖の構造的特徴 (2008)
  • Author(s): 山口圭子
  • Organizer: BMB2008(第31回日本分子生物学会年会・第81回日本生化学大会合同大会)
  • Place of Presentation: 神戸ポートアイランド、神戸市
• [Book] Experimental Glycoscience : Glycobiology(By N.Taniguchi et al.) (2008)
  • Author(s): N.Kawasaki, BY.Ma, T.Kawasaki
  • Total Pages: 498
  • Publisher: Springer
• [Book] Experimental Glycoscience Glycobiology Taniguchi N et al. Editors (2008)
  • Author(s): Nobuko Kawasaki
  • Total Pages: 498
  • Publisher: Springer
• [Remarks] ホームページ等
  • URL: http://www.glyco.is.ritsumei.ac.jp/RCG/
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  • URL: http://www.glyco.is.ritsumei.ac.jp/RCG
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  • URL: http://www.glyco.is.ritsumei.ac.jp/RCG/
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  • URL: http://www.glyco2.is.ritsumei.ac.jp/RCG/