Construction of an arteriosclerosis assessment system using genetically modified cells and animals, and drug development
| Project/Area Number |
20590078
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
OKANO Toshio Kobe Pharmaceutical University, 薬学部, 教授 (20131542)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAGAWA Kimie 神戸薬科大学, 薬学部, 講師 (90309435)
須原 義智 神戸薬科大学, 薬学部, 講師 (30297171)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 分子生物学 / 遺伝子改変細胞 / 遺伝子改変動物 / 動脈硬化モデル / ビタミンD / ビタミンK / 生合成酵素 / 活性評価 / 活性型ビタミンD / 受容体 / 活性化酵素 |
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| Research Abstract |
To elucidate the role of vitamin D in the prevention and treatment of arteriosclerosis, we have generated vitamin D receptor(VDR) gene knockout mice or vitamin D metabolically activating enzyme, CYP27B1 gene knockout mice together with the cells possessing genetically modified VDR or CYP27B1 gene, and have constructed an assessment system using the above cells and animals. We have found a novel human vitamin K biosynthesis enzyme, UBIAD1 and have constructed an assessment system at cellular level for the elucidation of the role of vitamin K in the prevention and treatment of arteriosclerosis.
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Report
(4 results)
Research Products
(113 results)
