Analysis of responsive factors for oxidative stress mediated by O-GlcNAc modification
Project/Area Number |
20590082
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
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Research Institution | Tokyo Metropolitan Institute of Gerontology |
Principal Investigator |
MIURA YURI Tokyo Metropolitan Institute of Gerontology, 東京都健康長寿医療センター研究所, 主任研究員 (00216574)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | シグナル伝達 / 酸化ストレス / アポトーシス / ストレス応答タンパク質 / 亜ヒ酸ナトリウム / O-GlcNAc / 熱ショックタンパク質 / 放射線 / ストレス / 脳・神経 |
Research Abstract |
In order to clarify the regulation mechanisms by O-GlcNAcylation in the signaling pathways caused by reactive oxygen species, the alteration of O-GlcNAcylated proteins due to oxidative stress and the effects of O-GlcNAcylation on the induction of stress responsive proteins were examined. The results suggest that O-GlcNAcylated proteins play a critical role of oxidative stress-responses, and that the induction of stress responsive protein is possible to be regulated by O-GlcNAcylation.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Proteomic Analysis of Plasma Proteins in Japanese Semisuper Centenarians.2011
Author(s)
Miura, Y., Sato, Y., Arai, Y., Abe, Y., Takayama, M., Toda, T., Hirose, N., Endo, T.
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Journal Title
Exp. Gerontol. 46
Pages: 81-85
Related Report
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[Journal Article] Translocation of lysosomal cathepsin D caused by oxidative stress or proteasome inhibition in primary cultured neurons and astrocytes.2010
Author(s)
Miura, Y., Sakurai, Y., Hayakawa, M., Shimada, Y., Zempel, H., Sato, Y., Hisanaga, S., Endo, T.
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Journal Title
Biol. Pharm. Bull 33
Pages: 22-28
NAID
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