Molecular Analysis of cognitive impairment associated with postmenopausal memory loss and Alzheimer's disease
| Project/Area Number |
20590083
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
TAKUMA Kazuhiro Osaka University, 大学院・薬学研究科, 准教授 (90289025)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アルツハイマー病 / 更年期障害 / エストロゲン / 海馬 / ミトコンドリア / コリン作動性神経系 / 神経変性 |
|---|
| Research Abstract |
Estrogen decline after menopause may influence cognitive performance and increase risk for Alzheimer's disease (AD) in women. We have previously found that combination of chronic stress and ovariectomy (OVX) causes memory impairment in mice. In this study, we found that cholinergic neuronal loss in the hippocampal CA3 region is involved in OVX/stress-induced memory impairment in mice, and donepezil and galantamine, which are clinically used for AD therapy, improved the memory impairment.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction2009
Author(s)
Kazuhiro Takuma, Fang Fang, Wensheng Zhang, Shiqiang Yan, Emiko Fukuzaki, Heng Du, Alexander Sosunov, Guy McKhann, Yoko Funatsu, Noritaka Nakamichi, Taku Nagai, Hiroyuki Mizoguchi, Daisuke Ibi, Osamu Hori, Satoshi Ogawa, David M.Stern, Kiyofumi Yamada, Shirley ShiDu Yan
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Journal Title
Proc.Natl.Acad.Sci.USA 106(47)
Pages: 20021-20026
Related Report
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[Journal Article] Matrix metalloprotease-9 inhibition improves amyloid β-mediated cognitive impairment and neurotoxicity in mice2009
Author(s)
Hiroyuki Mizoguchi, Kazuhiro Takuma, Emiko Fukuzaki, Daisuke Ibi, Eiichi Someya, Ko-hei Akazawa, Tursun Alkam, Hiroko Tsunekawa, Akihiro Mouri, Yukihiro Noda, Toshitaka Nabeshima, Kiyofumi Yamada
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Journal Title
J.Pharmacol.Exp.Ther. 331(1)
Pages: 14-22
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[Journal Article] Ovariectomy increases serum amyloid β peptide and hippocampal ABAD levels in mice2008
Author(s)
Emiko Fukuzaki, Kazuhiro Takuma, Yoko Funatsu, Yukiko Himeno, Yuko Kitahara, Hiroyuki Mizoguchi, Daisuke Ibi, Koji Koike, Masaki Inoue, Shi Du Yan, Kiyofumi Yamada
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Journal Title
Nuerochem.Int. 52(7)
Pages: 1358-1364
Related Report
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