Spinal Cord Injury : Establishment of Measurement for Electrophysiological Function and Pharmacological Evaluation of Drugs
| Project/Area Number |
20590086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Nagoya City University |
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Principal Investigator |
ONO Hideki Nagoya City University, 大学院・薬学研究科, 教授 (00080200)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Shohei 名古屋市立大学, 大学院・薬学研究科, 助教 (90433226)
TANABE Mitsuo 名古屋市立大学, 大学院・薬学研究科, 准教授 (20360026)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 脊髄損傷 / 運動機能評価 / 電気生理学的機能評価 / 脊髄反射 / セロトニン / 神経再生 |
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| Research Abstract |
This study aimed 1) to search effective drugs for the treatment of spinal cord injury (SCI) from clinically used therapeutics, 2) to establish evaluation method of nerve degeneration and/or renervation after SCI in electrophysiological function, and 3) to study effectiveness of selected drugs on protection and/or treatment of SCI in physiological function. The antidiabetic pioglitazone recovered motor disorder and prevented the appearance of neuropathic pain, and it prevented or recovered the electrophysiological function of descending serotonergic fibers to spinal motor systems.
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Report
(4 results)
Research Products
(12 results)
