Atypical beta-adrenoceptor in vascular smooth muscle : studies on the sensitivity to bupranolol and the effects of sympathetic nerve denervation
| Project/Area Number |
20590092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Toho University |
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Principal Investigator |
TANAKA Yoshio Toho University, 薬学部, 教授 (60188349)
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| Co-Investigator(Renkei-kenkyūsha) |
KASUYA Yoshitoshi 千葉大学, 大学院・医学研究院, 准教授 (70221877)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | β-アドレナリン受容体 / 異型β-アドレナリン受容体 / β3-アドレナリン受容体 / 血管平滑筋 / 腸間膜動脈 / プロプラノロール / ブプラノロール / 交感神経除神経 / β_3-アドレナリン受容体 / RT-PCR |
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| Research Abstract |
The present study was carried out to pharmacologically identify the subtype of beta-adrenoceptor that mediates relaxation of rat mesenteric artery, and to clarify the effects of chemical denervation of sympathetic nerve on beta-adrenoceptor functions, and the following new findings were obtained. 1) Beta-adrenoceptors that mediate relaxation of rat mesenteric artery are composed of two types : propranolol-sensitive and propranolol-insensitive beta-adrenoceptors. 2) Propranolol-sensitive beta-adrenoceptor is mainly beta-1 and propranolol-insensitive beta-adrenoceptor is beta-3. Beta-3 may have new pharmacological characteristics that are different from previous reports. 3) Chemical denervation of sympathetic nerves reduces the relaxant responses mediated through both beta-1 and beta-3.
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Report
(4 results)
Research Products
(25 results)
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[Presentation] リガンド依存性に活性化されるβ_3アドレナリン受容体シグナリングの多様性2009
Author(s)
堀之内孝広, 佐藤将哲, Hutchinson, D. S., Evans, B. A., 田中芳夫, 小池勝夫, 三輪聡一, Summers, R. J.
Organizer
第82回 日本薬理学会年会
Place of Presentation
横浜市
Related Report
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