| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The present study was carried out to pharmacologically identify the subtype of beta-adrenoceptor that mediates relaxation of rat mesenteric artery, and to clarify the effects of chemical denervation of sympathetic nerve on beta-adrenoceptor functions, and the following new findings were obtained. 1) Beta-adrenoceptors that mediate relaxation of rat mesenteric artery are composed of two types : propranolol-sensitive and propranolol-insensitive beta-adrenoceptors. 2) Propranolol-sensitive beta-adrenoceptor is mainly beta-1 and propranolol-insensitive beta-adrenoceptor is beta-3. Beta-3 may have new pharmacological characteristics that are different from previous reports. 3) Chemical denervation of sympathetic nerves reduces the relaxant responses mediated through both beta-1 and beta-3.
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