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Role of lymphocytic cholinergic system in regulation of fat metabolism

Research Project

Project/Area Number 20590096
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionDoshisha Women's College of Liberal Arts

Principal Investigator

FUJII Takeshi  Doshisha Women's College of Liberal Arts, 薬学部, 准教授 (80255380)

Co-Investigator(Kenkyū-buntansha) TAKATORI Yuki  同志社女子大学, 薬学部, 助教 (90411090)
Co-Investigator(Renkei-kenkyūsha) KAWASHIMA Koichiro  武蔵野大学, 薬学研究所, 客員教授 (70095008)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアセチルコリン / リンパ球 / 肥満 / コリンアセチルトランスフェラーゼ / ムスカリン受容体 / ニコチン受容体 / acetylcholine / muscarinic receptor / nicotinic receptor / Lymphocyte / choline acetyltransferase / obesity
Research Abstract

We investigated the involvement of non-neuronal cholinergic system in lymphocytes in fat metabolism. Acetylcholine (ACh) production, activity and mRNA expression of choline acetyltransferase (ChAT), an ACh-synthesizing enzyme, in ob/ob mice, an animal model of type 2 obese diabetes, is reduced when compared with that of control (lean) mice. Lymphocytic cholinergic activity increased with age. These findings suggest that lymphocytic cholinergic system is involved in regulation of fat metabolism.

Report

(5 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Products Report
  • Research Products

    (10 results)

All 2011 2010 2009 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] 免疫機能とムスカリン受容体2011

    • Author(s)
      藤井健志、高鳥悠記
    • Journal Title

      鼻アレルギーフロンティア 11

      Pages: 36-41

    • Related Report
      2010 Final Research Report
  • [Journal Article] Acetylcholine synthesis and release in NIH3T3 cells co-expressing the high-affinity choline transporter and choline acetyltransferasae.2009

    • Author(s)
      Fujii T, Masai M, Misawa H, Okuda T, Takada-Takatori Y, Moriwaki Y, Haga T, Kawashima K.
    • Journal Title

      Journal of Neuroscience Research. 87

      Pages: 3024-3032

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acetylcholine synthesis and release in NIH3T3 cells co-expressing the high-affinity choline transporter and choline acetyltransferase

    • Author(s)
      Fujii T
    • Journal Title

      Journal of Neuroscience Research (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] SLURP-1によるTリンパ球からのアセチルコリン遊離促進2011

    • Author(s)
      藤井健志、高鳥悠記、川島紘一郎
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      神奈川
    • Year and Date
      2011-03-23
    • Related Report
      2010 Final Research Report
  • [Presentation] SLURP-1によるTリンパ球からのアセチルコリン遊離促進2011

    • Author(s)
      藤井健志
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] SLURP-1によるTリンパ球からのアセチルコリンの遊離促進2011

    • Author(s)
      藤井 健志
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県)
    • Year and Date
      2011-03-23
    • Related Report
      Products Report
  • [Presentation] メディエートフォアを介するT細胞からのアセチルコリン遊離機構2010

    • Author(s)
      藤井健志、高鳥悠記、川島紘一郎
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-17
    • Related Report
      2010 Final Research Report
  • [Presentation] メディエートフォアを介するT細胞からのアセチルコリン遊離機構2010

    • Author(s)
      藤井健志
    • Organizer
      第83回日本薬理学会年会
    • Place of Presentation
      大阪国際会議場(大阪府)
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] リンパ球における非神経性コリン作動系の発現と免疫調節機構2009

    • Author(s)
      藤井健志、高鳥悠記、川島紘一郎
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] リンパ球における非神経性コリン作動系の発現と免疫機能調節2009

    • Author(s)
      藤井健志
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-09-09  

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