| Project/Area Number |
20590103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
|
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| Research Institution | Hiroshima University |
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Principal Investigator |
MATSUNAMI Katsuyoshi Hiroshima University, 大学院・医歯薬学総合研究科, 准教授 (70379890)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Hideaki 広島大学, 大学院・医歯薬学総合研究科, 教授 (00107385)
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| Co-Investigator(Renkei-kenkyūsha) |
TAHARA Hidetoshi 広島大学, 大学院・医歯薬学総合研究科, 教授 (00271065)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 生物活性物質 / がん / 沖縄産植物 / 増殖抑制 / トランスポーター / テロメラーゼ / ルシフェラーゼ / 多剤耐性 |
|---|
| Research Abstract |
Several biologically active compounds were isolated from the Okinawan subtropical plants. These compounds could inhibit the tumor cell growth and/or inhibit the multidrug resistance activity of cultured cell, which are clinically important features for cancer chemotherapy. The absolute structures of the isolated compounds were elucidated by spectroscopic and chemical modification analysis. The results were published in international scientific journals.
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