Analysis of antiseptic resistance in yeast.
| Project/Area Number |
20590119
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
OHASHI Kazuaki Iwate Medical University, 薬学部, 准教授 (70344679)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 薬学 / 酵母 / 衛生 |
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| Research Abstract |
So far I clarified overexpression of SGE1 in yeast confers resistance to benzalkonium chloride and chlorhexidine. Effect of overexpression or deletion of AZR1, VBA3 and VBA5 to antiseptic sensitivity in yeast was examined. Overexpression of these genes did not confer resistance to benzalkonium chloride nor chlorhexidine in yeast. Deletion of SGE1, AZR1, VBA3 and VBA5 did not affect sensitivity to benzalkonium chloride nor chlorhexidine. Yeast deletion mutants showing resistance or sensitive to benzalkkonium chloride were screened to obtain numerous candidates.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Normal formation of a subset of intestinal granules in Caenorhabditis elegans requires ATP-binding cassette transporters HAF-4 and HAF-9, which are highly homologous to human lysosomal peptide transporter TAP-like.2009
Author(s)
Hiromi Kawai, Takahiro Tanji, Hirohisa Shiraishi, Mitsuo Yamada, Ryoko Iijima, Takao Inoue, Yasuko Kezuka, Kazuaki Ohashi, Yasuo Yoshida, Koujiro Tohyama, Keiko Gengyo-Ando, Shohei Mitani, Hiroyuki Arai, Ayako Ohashi-Kobayashi, Masatomo Maeda
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Journal Title
Mol.Biol.Cell 20
Pages: 2979-2990
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[Presentation] Sera from Japanese diabetes patient show autoimmunity to REG family antigens.2009
Author(s)
Nausheen J. Shervani, Koji Nata, Naoya Noguchi, Iwao Takahashi, Takayuki Ikeda, Kazuaki Ohashi, Takeo Yoshikawa, Akira Uruno, Shin Takasawa, Hiroshi Okamoto, Akira Sugawara
Organizer
第82回日本生化学会大会
Place of Presentation
神戸
Year and Date
2009-10-23
Related Report
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