Analysis of mode of cytokine secretion in respiratory tracts of influenza-virus infected mice at the early phase of infection.
| Project/Area Number |
20590131
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kyushu University of Health and Welfare |
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Principal Investigator |
MASAHIKO Kurokawa Kyushu University of Health and Welfare, 薬学部, 教授 (80186527)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Wataru 九州保健福祉大学, 薬学部, 教授 (50399218)
SHIMIZU Tomomi 九州保健福祉大学, 薬学部, 助教 (80412831)
YOSHIDA Hiroki 九州保健福祉大学, 薬学部, 助教 (90469411)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 微生物 / 感染症学 / インフルエンザ / ウイルス感染症 / サイトカイン / 気道 |
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| Research Abstract |
In the influenza infection, cytokines are produced in respiratory tracts and their production is important in promoting host-immune defense to alleviate symptoms especially in the early stage of infection. Using murine intranasal infection model, we examined the cascade of cytokine production after infection and found that IL-12 was produced by macrophages infiltrating the infected epitherium as the first response cytokine. Also, in influenza virus-infected mice administered 7-hydroxycoumarin that can modulate cytokine production in macrophage-like P388D1 cells, we revealed that the modulation of inflammatory cytokines in the respiratory tracts of infected mice was critical to alleviate influenza symptoms. Thus, it was suggested that the modulators of cytokine production are the candidates of effective anti-influenza agents in alleviation of the symptoms.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Functional disorder of primary immunity responding to respiratory syncytial virus infection in offspring mice exposed to flame retardant, decabrominated diphenyl ether, perinatally.2010
Author(s)
Watanabe, W., Shimizu, T., Sawamura, R., Hino, A., Konno, K., Kurokawa, M
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Effects of tetrabromobisphenol A, a brominated flame retardant, on the immune response to respiratory syncytial virus infection in mice.2010
Author(s)
Watanabe, W., Shimizu, T., Sawamura, R., Hino, A., Konno, K., Hirose, A., Kurokawa, M.:
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Journal Title
International Immunopharmacology 10
Pages: 393-397
Related Report
Peer Reviewed
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[Journal Article] Antiviral activities of diarylheptanoids against influenza virus in vitro.2010
Author(s)
Sawamura, R., Sun, Y., Yasukawa, K., Shimizu, T., Watanabe, W., Kurokawa, M.
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Journal Title
J.Nat.Med. 64
Pages: 117-120
NAID
Related Report
Peer Reviewed
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[Journal Article] Interleukin 12 is a primary cytokine responding to influenza virus infection in the respiratory tract of mice.2009
Author(s)
Hama, Y., Kurokawa, M., Imakita, M., Yoshida, Y., Shimizu, T., Watanabe, W., Shiraki, K.
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Journal Title
Acta virologica 53
Pages: 233-240
Related Report
Peer Reviewed
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[Presentation] ジアリルヘプタノイド類の単純ヘルペス1型、ポリオ、麻疹、RSウイルスに対する抗ウイルス活性の検討2009
Author(s)
紺野克彦, 澤村理英, 清水寛美, 渡辺渡, 三浦基文, 鳥山正晴, 滝戸俊夫, 本橋重康, 加藤雅彦, 山本隆一, 安川憲, 黒川昌彦
Organizer
第26回日本薬学会九州支部大会
Place of Presentation
福岡
Related Report
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