| Project/Area Number |
20590135
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | National Institute for Minamata Disease |
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Principal Investigator |
FUJIMURA Masatake National Institute for Minamata Disease, 基礎研究部, 室長 (20416564)
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| Co-Investigator(Kenkyū-buntansha) |
USUKI Fusako 国立水俣病総合研究センター, 臨床部, 室長 (50185013)
IZUMO Shuji 鹿児島大学, 医学部, 教授 (30143811)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 中毒学 / 環境毒 / 神経機能障害 / ローキナーゼ阻害薬 / 環境 / 再生医学 / 脳神経疾患 / 薬理学 |
|---|
| Research Abstract |
We mainly show that inhibition of the Rho kinase pathway prevents MeHg-intoxication. 2 Rho kinase inhibitors, Fasudil and Y-27632, significantly protected against axonal degeneration and apoptotic cell death in cultured cortical neuron exposed to MeHg. Fasudil also prevented the neuronal degeneration in peripheral nerves and hind limb crossing sign in MeHg-intoxicated model rats. Furthermore, Rho kinase inhibitors were effective for axonal degeneration and cell death in cultured cortical neuron exposed to inorganic mercury or Rotenone as a candidate substance responsible for Parkinson disease.
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