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Role of ileal bile acid absorption on regulation of serum cholesterol levels

Research Project

Project/Area Number 20590137
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionTohoku University

Principal Investigator

MIYATA Masaaki  Tohoku University, 大学院・薬学研究科, 助教 (90239418)

Co-Investigator(Kenkyū-buntansha) YOSHINARI Kouichi  東北大学, 大学院・薬学研究科, 准教授 (60343399)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsASBT / コレステロール / 胆汁酸 / FXR / 腸内細菌 / 抗菌薬 / 回腸胆汁酸吸収 / 二次胆汁酸 / アンピシリン / 消化管吸収 / 発現調節
Research Abstract

Intestinal bile acid absorption is negatively regulated through cholesterol signaling in an FXR-independent manner. Intestinal bile acid absorption is also regulated through enterobacteria-mediated bile acid transformation.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009 2008 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (22 results) Remarks (1 results)

  • [Journal Article] Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression2011

    • Author(s)
      M.Miyata, H.Yamakawa, M.Hamatsu, H.Kuribayashi, Y.Takamatsu, Y.Yamazoe
    • Journal Title

      J.Pharmacol.Exp.Ther. 336

      Pages: 188-196

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression2011

    • Author(s)
      M.Miyata, et al.
    • Journal Title

      J.Pharmacol.Exp.Ther.

      Volume: 336 Pages: 188-196

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible protective-role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.2010

    • Author(s)
      M.Miyata, M.Nomoto, F.Sotodate, T.Mizuki, W.Hori, M.Nagayasu, S.Yokokawa, S.Ninomiya, Y.Yamazoe.
    • Journal Title

      Eur.J.Pharmacol. 636

      Pages: 145-154

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible protcctive-role of pregnenolone-16α-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis.2010

    • Author(s)
      M.Miyata, et al.
    • Journal Title

      Eur.J.Pharmacol

      Volume: 636 Pages: 145-154

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2009

    • Author(s)
      M.Miyata, Y.Takamatsu, H.Kuribayashi, Y.Yamazoe.
    • Journal Title

      J.Pharmacol.Exp.Ther. 331

      Pages: 1079-1085

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed Fxr-null mice : FXR-independent suppression of intestinal bile acid absorption2009

    • Author(s)
      M.Miyata, Y.Matsuda, M.Nomoto, Y.Takamatsu, N.Sato, M.Hamatsu, P.A.Dawson, F.J.Gonzalez, Y.Yamazoe.
    • Journal Title

      Drug Metab.Dispos. 37

      Pages: 338-344

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF15 expression2009

    • Author(s)
      M.Miyata, et al.
    • Journal Title

      J.Pharmacol.Exp.Ther. 331

      Pages: 1079-1085

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cholesterol feeding prevents hepatic accumulation of bile acids in cholic acid-fed Fxr-null mice : FXR-independent suppression of intestinal bile acid absorption2009

    • Author(s)
      M. Miyata, et.al.
    • Journal Title

      Drug Metab. Dispos. 37

      Pages: 338-344

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPARa gene expression is up-regulated by LXR and PXR activators in the small intestine.2008

    • Author(s)
      J.Inoue, S.Satoh, M.Kita, M.Nakahara, S.Hachimura, M.Miyata, T.Nishimaki-Mogami, R.Sato
    • Journal Title

      Biochem.Biophys.Res.Commun. 371

      Pages: 675-678

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPARa gene expression is up-regulated by LXR and PXR activators in the small intestine2008

    • Author(s)
      J. Inoue, et.al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 371

      Pages: 675-678

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 胆汁酸代謝を介する腸内細菌による回腸エンドクラインホルモンFGF15の発現調節2011

    • Author(s)
      宮田昌明, 他3名
    • Organizer
      第131回日本薬学会年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腸内細菌は胆汁酸代謝を介した回腸ASBT発現抑制により宿主の胆汁酸吸収を制御する2010

    • Author(s)
      山川泰輝、栗林秀明、宮田昌明、山添康
    • Organizer
      第32回胆汁酸研究会
    • Place of Presentation
      仙台
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 抗菌薬投与は胆汁酸トランスポーター、合成酵素の発現亢進を介して胆汁酸ホメオスタシスを変動させる2010

    • Author(s)
      宮田昌明、山川泰輝、栗林秀明、濱津真由美、高松裕樹、山添康
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 腸内細菌は回腸ASBT 発現を介して消化管の胆汁酸吸収を調節する2010

    • Author(s)
      山川泰輝、宮田昌明、栗林秀明、高松裕樹、濱津真由美、山添康
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 腸内細菌は回腸ASBT発現を介して消化管の胆汁酸吸収を調節する2010

    • Author(s)
      山川泰輝, 他5名
    • Organizer
      第25回日本薬物動態学会
    • Place of Presentation
      大宮
    • Year and Date
      2010-10-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗菌薬による腸内細菌叢の変動は回腸胆汁酸吸収トランスポーターASBTの発現上昇に関与する2010

    • Author(s)
      宮田昌明、山川泰輝、栗林秀明、濱津真由美、山添康
    • Organizer
      第37回日本トキシコロジー学会年会
    • Place of Presentation
      宜野湾
    • Year and Date
      2010-06-17
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] Enterobacteria alter bile acid homeostasis through FXR-FGF15/19 system2010

    • Author(s)
      山添康, 高松裕樹, 栗林秀明, 山川泰輝, 宮田昌明
    • Organizer
      Microsomal Drug Oxidation
    • Place of Presentation
      Beijin, Chaina
    • Year and Date
      2010-05-18
    • Related Report
      2010 Final Research Report
  • [Presentation] Administration of ampicillin increases ileal Asbt protein amounts resulting in reduction of fecal bile acid excretion in mice.2010

    • Author(s)
      山添康, 高松裕樹, 濱津真由美, 宮田昌明
    • Organizer
      2010 Experimental Biology
    • Place of Presentation
      Anaheim USA
    • Year and Date
      2010-04-27
    • Related Report
      2010 Final Research Report
  • [Presentation] Administration of ampicillin elevates hepatic primary bile acid synthesis through suppression of ileal FGF 15 expression.2010

    • Author(s)
      Masaaki Miyata, 他3名
    • Organizer
      2010 Experlmental Biology
    • Place of Presentation
      Anaheim, USA
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Administration of ampicillin increases ileal Asbt protein amounts resulting in reduction of fecal bile acid exeretion in mice.2010

    • Author(s)
      Yasushi Yamazoe, 他4名
    • Organizer
      2010 Experimental Biology
    • Place of Presentation
      Anaheim USA
    • Year and Date
      2010-04-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] アンピシリン投与はマウス回腸の胆汁酸吸収トランスポータータンパク含量を増加させ、糞中胆汁酸排泄を低下させる2010

    • Author(s)
      宮田昌明、山川泰輝、濱津真由美、高松裕樹、山添康
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 抗菌薬の投与は回腸FGF15の発現低下を介して一次胆汁酸合成を増加させる2009

    • Author(s)
      宮田昌明, 他3名
    • Organizer
      第24回 日本薬物動態学会
    • Place of Presentation
      京都
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 消化管FGF15の発現変動と胆汁酸組成2009

    • Author(s)
      宮田昌明, 他4名
    • Organizer
      第31回胆汁酸研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] アンピシリン投与による肝内胆汁酸濃度上昇における消化管と肝臓の寄与2009

    • Author(s)
      濱津真由美、高松裕樹、宮田昌明、山添康
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 腸内細菌ーFGF系による肝胆汁酸レベルの調節2009

    • Author(s)
      宮田昌明、高松裕樹、山添康
    • Organizer
      第36回日本トキシコロジー学会年会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 腸内細菌-FGF系による肝胆汁酸レベルの調節2009

    • Author(s)
      宮田昌明, 他2名
    • Organizer
      第36回日本トキシコロジー学会年会
    • Place of Presentation
      盛岡
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂質とFXR control2008

    • Author(s)
      宮田昌明(他3名)
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗生物質投与による肝内胆汁酸濃度上昇とその機序2008

    • Author(s)
      高松裕樹、宮田昌明,山添康
    • Organizer
      第47回日本薬学会東北支部会
    • Place of Presentation
      盛岡
    • Year and Date
      2008-10-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗菌薬投与による肝内胆汁酸濃度の上昇と回腸FGF15の発現抑制2008

    • Author(s)
      宮田昌明(他2名)
    • Organizer
      第30回胆汁酸研究会
    • Place of Presentation
      広島
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] 核内受容体FXRの欠損は、肝内胆汁酸濃度の上昇を引き起こし、酸化ストレスの生成を促進する2008

    • Author(s)
      宮田昌明(他2名)
    • Organizer
      第5回東日本胆汁酸研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] アンピシリン併用により生ずるコール酸誘発肝障害と胆汁酸動態2008

    • Author(s)
      高松裕樹、宮田昌明、山添康
    • Organizer
      第35回日本トキシコロジー学会学術年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2010 Final Research Report
  • [Presentation] コレステロールによる肝内胆汁酸レベルの調節機序の解明-Fxr欠損マウスによる解析2008

    • Author(s)
      佐藤望未(他5名)
    • Organizer
      日本薬学会第128回年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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