Effect of estrogen receptor polymorphisms on clinical drug usage
| Project/Area Number |
20590138
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
UENO Koichi Chiba University, 大学院・薬学研究院, 教授 (60125903)
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| Co-Investigator(Renkei-kenkyūsha) |
AMANO Keiko 千葉県立東金病院, 副院長 (70167956)
SUZUKI Masahiko 千葉大学, 医学部附属病院・整形外科・フロンティアメディカル工学研究開発センター, 教授 (10312951)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 薬学 / 薬剤反応性 / 臨床 / 遺伝子 / 薬理 / エストロゲン受容体 / 遺伝子多型 / 更年期障害 / 性差 / 臨床研究 / マイクロサテライト多型 / 医薬品適正使用 / 漢方治療 / 関節リウマチ / 薬剤相関性 |
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| Research Abstract |
To investigate the possible influence of the polymorphism of the estrogen receptor-β gene against menopausal disease and rheumatoid arthritis (RA). As a result, it was found that CA repeat polymorphism affected on the sensitivity to a Kampo-drug, keishibukuryogan. On the other hand, Rsa polymorphism was revealed to have significant relationship to RA severity. These results could contribute to improve the clinical use of drugs based on gender specific medicine.
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Report
(4 results)
Research Products
(88 results)
